|AMP > Introduction : The importance of AMPs
Peptides of the defensin, cathelicidin,
thrombocidin and histatin classes are found in humans protecting
epithelia against invading microorganims and assisting neuthrophils and
platelets (Peschel, 2002).. In the
airways, α-and-β-defensins and the cathelicidin LL-37/hCAP-18 are
produced by the respiratory epithelium and alveolar macrophages and
then secreted into the airway surface fluid . Beyond their
antimicrobial function, these peptides are known to be multi-functional.
In fact, it has been demonstrated their multiple roles as mediators of
inflammation with effects on epithelial and inflammatory cells, and the
impact these roles have over such diverse processes as proliferation,
immune induction, wound healing, cytokine release, chemotaxis,
protease–antiprotease balance, and redox homeostasis (Com et al. 2003; Liu et al. 2003).
PESCHEL, A. How do
bacteria resist human antimicrobial peptides? Trends
in Microbiology, 2002, vol. 10, no. 4, p. 179-196.
COM, E.; BOURGEON,
F.; EVRARD, B.; GANZ, T.; COLLEU, D.; JEGOU, B. and
PINEAU, C. Expression of antimicrobial defensins in the male
reproductive tract of rats, mice, and humans. Biology of
Reproduction, 2003, vol. 68, p. 95-104.
LIU, L.; ROBERTS, A.A. and GANZ, T. By IL-1 Signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. Journal of Immunology, 2003, vol. 170, no. 1, p. 575-580.