| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| SP1 | Sp1 transcription factor | Transcription Factor | SP1 is involved in prostate cancer cell motility as microRNA miR-330 mediated inhibition of SP1 is associated with reduction of cell motility in prostate cancer. | Reference |
| LPXN | Leupaxin | Adaptor Protein | Leupaxin(LPXN) is involved in prostate cancer cell migration through coacivator of Androgen receptor(AR) dependent way in LNCaP cell line. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | Inhibition of the Jak2 tyrosine kinase results in activation of Stat3 and prostate cancer cell motility in both DU145 and PC-3 cells. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | STAT3 promotes prostate cancer cell motility through Integrin beta 6 mediated signaling. | Reference |
| STAT3 | Signal transducer and activator of transcription 3 (acute-phase response factor) | Transcription Factor | STAT3 promotes prostate cancer cell motility through JAK2/STAT3 signaling. | Reference |
| SMAD3 | SMAD family member 3 | Transcription Regulatory Protein | SMAD3 is associated with prostate cancer cell adhesion as a mediator of growth and differentiation factor-9(GDF-9) dependent signaling and activation of FAK and paxillin in PC-3 prostate cancer cells. | Reference |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | GTPase | RAC1 is involved in prostate cancer cell motility driven by 14-3-3 zita dimerization. | Reference |
| BAG3 | BCL2-associated athanogene 3 | Adaptor Protein | In several prostate cancer cell line, overexpression of BAG3 enhances cell motility in prostate cancer cells | Reference |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Adaptor Protein | 14-3-3zeta enhances prostate cancer cell-matrix interactions, motility and transendothelial migration via activation of Rac1-GTPase | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | Critically involved in prostate cancer cell motility, regulates AR,MMP2,MMP9 expression. | Reference |
| BCAR1 | Breast cancer anti-estrogen resistance 1 | Adaptor Protein | BCAR1-CRKII complex functions as a 'molecular switch' in regulation of cell motility in metastatic prostate cancer cell line Du145 | Reference |
| IRS1 | Insulin receptor substrate 1 | Adaptor Protein | Regulates cell motility in androgen independent prostate cancer cell line and is phosphorylated by PI3K. | Reference |
| TGFBR2 | Transforming growth factor, beta receptor II | Receptor Serine/threonine Kinase | TGFBR2 promotes cell motility | Reference |
| IGF1R | Insulin-like growth factor 1 receptor | Receptor Tyrosine Kinase | IGF1R is involved in androgen independent prostate cancer cell motility through modulation of alphavbeta3 integrin and PI3-K/Akt signaling pathway. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | EPHA2 is involved in prostate cancer cell motility as overexpression of EPHA2 promotes prostate cancer cell motility in PC-3 cells in ligand independent manner. | Reference |
| EPHA2 | EPH receptor A2 | Receptor Tyrosine Kinase | EPHA2 is involved in prostate cancer cell motility by adopting an amoboid movement based on Rho-mediated cell rounding. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen receptor is involved in prostate cancer cell motility through SRC-FAK-PI3K-CDC42-RAC1 cascade. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen receptor stimulates PAK6 by direct interaction and PAK6 activation enhance prostate cancer cell motility & Cell Invasion | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen receptor stimulates PAK6 by direct interaction and PAK6 activation enhance prostate cancer cell motility & invasion | Reference |
| MAPK3 | Mitogen-activated protein kinase 3 | Serine/Threonine Kinase | MAPK3(ERK1) phosphorylation in response of human chorionic gonadotropin beta (hCGbeta) is associated with prostate cancer cell motility. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 is involved in prostate cancer cell motility in an integrin alpha(v)beta(3) dependent manner. | Reference |
| CDK5 | Cyclin-dependent kinase 5 | Serine/Threonine Kinase | CDK5 is involved in the regulation of prostate cancer cell motility. | Reference |
| JAK2 | Janus kinase 2 | Tyrosine Kinase | JAK2 is involved in prostate cancer cell motility through JAK2-STAT3 mediated signaling as JAK2 inhibition results in reduced activation of STAT3 and suppression of prostate cancer cell motility. | Reference |
| FYN | FYN oncogene related to SRC, FGR, YES | Tyrosine Kinase | FYN is involved in the prostate cancer cell motility through both integrin and receptor tyrosine kinase mediated manner. | Reference |
| SRC | V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | Tyrosine Kinase | SRC is involved in the prostate cancer cell motility along with FAK. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Paxillin is involved in the prostate cancer cell motility in a GDF9 responsive way and SMAD dependent manner in PC-3 prostate cancer cell line. | Reference |
| WASF3 | WAS protein family, member 3 | Cytoskeletal Associated Protein | WASF3 play an important role in prostate cancer cell motility in a IL6 responsive way mediated by JAK2/STAT3 signaling. | Reference |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Adhesion Molecule | Influences prostate cancer cell motility through E-cadherin and PKD1. | Reference |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | Adaptor Protein | Function as a switch in regulation of cell motility in prostate cancer. | Reference |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adaptor Protein | Promotes cell motility in a bradykinine responsive manner and through PI3K/AKT1 pathway. | Reference |
| EGFR | Epidermal growth factor receptor | Receptor Tyrosine Kinase | Promotes prostate cancer cell motility through AKT1. | Reference |
| FAK | Protein tyrosine kinase 2 | Tyrosine Kinase | Functions in MIC-1 mediated actin reorganization through FAK-RhoA signaling pathway in both androgen dependent and independent prostate cancer cell line | Reference |
| UBE2T | Ubiquitin conjugating enzyme E2T | Ubiquitin proteasome system protein | Ubiquitin-conjugating enzyme E2T (UBE2T), which is highly expressed in human prostate cancer, plays a role in human prostate cancer associated cell motility. | Reference |
| TLN1 | Talin 1 | Cytoskeletal associated protein | Talin 1, overexpressed in human prostate cancer and is significantly associated with prostate cancer cell motiility. | Reference |
| LCN2 | Lipocalin 2 | Transport/Cargo Protein | Lipocalin 2 (LCN2), a member of the lipocalin family, is highly expressed in human prostate cancer and plays a role in enhancement of prostate cancer associated cell motility. | Reference |
| YAP1 | Yes associated protein 1 | Transcription Regulatory Protein | Yes-associated protein (YAP), a crucial effector of the hippo tumor suppressor pathway, plays a role in the regulation of human prostate cancer associated cell motility. | Reference |
| AQP3 | Aquaporin 3 | Water Channel | Aquaporin 3 (AQP3) critically mediated human prostate cancer associated cell motility through upregulation of MMP3 expression via ERK1/2 activation. | Reference |
| SPAG9 | Sperm associated antigen 9 | Integral Membrane Protein | Sperm-associated antigen 9 (SPAG9), which is highly expressed in human prostate cancer, plays a role in promotion of prostate cancer associated cell motility and there by facilitates metastatic progression. | Reference |