| Protein | Protein Name | Molecular Type | Evidence | Reference |
|---|
| E2F1 | E2F transcription factor 1 | Transcription Factor | E2F1 is associated with cell cycle regulation in prostate cancer as targeted reduction in activity of E2F1 results in reduction of cell cycle regulatory programs in prostate cancer. | Reference |
| PHB | Prohibitin | Adaptor Protein | Prohibitin(PHB) has a nuclear regulatory role in prostate cancer. | Reference |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Cell Cycle Control Protein | CDKN1A(p21) play an important role in prostate cancer cell cycle arrest along with CDK4. | Reference |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Cell Cycle Control Protein | CDKN1A(p21) play an important role in prostate cancer cell cycle arrest along with CDK4. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | AKT1 mediates an enhancement of Skp2 expression and there by promotes p27 destruction, that results in prostate cancer cell cycle deregulation. | Reference |
| AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Serine/Threonine Kinase | PI3K/AKT1 mediates prostate cancer cell cycle deregulation through the activation of AKT/mTOR/p70(S6K) signaling pathway | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | PLK1 is overexpressed in prostate cancer and associated with deregulation of cell cycle and mitotic entry. | Reference |
| PLK1 | Polo-like kinase 1 | Serine/Threonine Kinase | Polo-like kinase 1 (PLK1) is associated with mitotic mechinery in prostate cancer as Si RNA mediated silencing of PLK1 results in mitotic cell cycle arrest and defects in centrosome integrity. | Reference |
| AR | Androgen receptor | Nuclear Receptor | Androgen receptor(AR) plays a very crucial role in androgen independent prostate cancer cell cycle progression through upregulation of M-phase cell cycle genes. | Reference |
| PXN | Paxillin | Cytoskeletal Associated Protein | Paxillin, a cytoplasmic adaptor protein is significantly involved in prostate cancer cell cycle through regulating c-FOS and cyclin D1 expression. | Reference |
| FGFR1 | Fibroblast growth factor receptor 1 | Receptor Tyrosine Kinase | FGFR-1 plays a role in prostate cancer cell cycle progression, through mediating G2 to M phase transition. | Reference |
| FADD | Fas (TNFRSF6)-associated via death domain | Adaptor Protein | Adapter protein FADD is critically involved in prostate cancer associated G2 to M phase cell cycle transition. | Reference |
| BCL2L1 | BCL2-like 1 | Adaptor Protein | BCL2L1(BCL-XL), which is overexpressed in human prostate cancer plays a role in G1 to S phase transition of prostate cancer cell cycle in an androgen receptor(AR) dependent manner. | Reference |
| DVL2 | Dishevelled segment polarity protein 2 | Adaptor Protein | DVL2 plays a role in G1 to S phase transition of prostate cancer cell cycle by targeting cyclin D1 through KIF3a-DVL2-?-catenin axis. | Reference |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | Ubiquitin Proteasome System Protein | F-box protein Skp2, an oncoprotein plays an important role in human prostate cancer progression through regulation of multiple cell cycle regulators including p27, p21 and FOXO1. | Reference |
| FUS | FUS RNA binding protein | RNA binding protein | FUS/TLS (Fused in Ewing's Sarcoma/Translocated in Liposarcoma) plays a significant role in human prostate cancer associated cell cycle progression in an androgen receptor(AR) dependent manner. | Reference |
| SOX2 | SRY-box 2 | Transcription Factor | SOX2 plays a critical role in prostate cancer cell cycle progresson through regulation of cyclin E and p27. | Reference |
| UBE2C | Ubiquitin conjugating enzyme E2C | Ubiquitin Proteasome System Protein | UBE2C plays a role in human prostate cancer cell cycle progression, particularly in G2 to M phase. | Reference |
| MED12 | Mediator complex subunit 12 | Transcription Regulatory Protein | MED12, overexpressed in castration resistant prostate cancer and plays a role in G1 to S phase cell cycle transition. | Reference |
| LAT1 | Solute carrier family 7 (amino acid transporter light chain, L system), member 5 | Transport/Cargo Protein | LAT1, a L-type amino acid transporter, is involved in G2 to M phase transition of human prostate cancer associated cell cyle and there by enhances metastatic castration resistant prostate cancer progression. | Reference |
| LAT3 | Solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | Transport/Cargo Protein | LAT3, a L-type amino acid transporter, is involved in G2 to M phase transition of human prostate cancer associated cell cyle and there by enhances metastatic castration resistant prostate cancer progression. | Reference |
| ADAM17 | ADAM metallopeptidase domain 17 | Metallo protease | ADAM17, a transmembrane protein mediates prostate cancer cell cycle progression through EGFR/PI3K/AKT pathway and targets cell cycle regulator p21 and p27. | Reference |
| HOXB13 | Homeobox B13 | Transcription Factor | HOXB13, overexpressed in human prostate cancer and plays a crucial role in G1 to S phase and G2 to M phase cell cycle transition. | Reference |
| CDK1 | Cyclin-dependent kinase 1 | Serine/Threonine Kinase | Cyclin-dependent kinase 1 (CDK1) plays a leading role in prostate cancer cell cycle progression through inhibition of tumour suppressor FOXO1. | Reference |
| ADAM9 | ADAM metallopeptidase domain 9 | Metallo protease | ADAM9 plays a significant role in prostate cancer cell cycle progression, particularly G1 to S phase transition through regulation of p27 ina REG4 dependent manner. | Reference |
| CDK6 | Cyclin-dependent kinase 6 | Cell Cycle Control Protein | Cyclin-dependent kinase 6 (CDK6) is associated with G1 to S phase transition of prostate cancer cell cycle through enhancement of androgen receptor activity. | Reference |
| BIRC7 | Baculoviral IAP repeat containing 7 | Unclassified | BIRC7(Livin alpha) promotes human prostate cancer cell cycle progresion through regulation of G1 to S phase transition. | Reference |
| CUL1 | Cullin 1 | Ubiquitin proteasome system protein | Cullin-1 (CUL1), which is highly expressed in human prostate cancer, is involved in prostate cancer associated cell proliferation through regulation of cell cycle by regulating the expression of cyclin D, cyclin E, p21 and p27. | Reference |