A literature extracted depiction of events associated with alternative pathway mediated transactivation of Androgen Receptor (AR) signaling during human prostate cancer tumorigenesis and progression. Color code-Green depicts Over expressed protein, Orange indicates Scaffolding protein, Red indicates Tumour Suppressors and Pink dotted edge indicates Modulation.
| ACK1 | Tyrosine kinase, non-receptor, 2 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 |
| AR | Androgen Receptor |
| ATM | ATM serine/threonine kinase |
| c-FLIP | CASP8 and FADD-like apoptosis regulator |
| c-FOS | FBJ murine osteosarcoma viral oncogene homolog |
| c-JUN | Jun proto-oncogene |
| c-MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| c-SRC | SRC proto-oncogene, non-receptor tyrosine kinase |
| CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2, beta |
| CCND1 | Cyclin D1 |
| CD168 | Hyaluronan-mediated motility receptor |
| CDK5 | Cyclin-dependent kinase 5 |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 |
| DAB2IP | DAB2 interacting protein |
| DVL2 | Dishevelled segment polarity protein 2 |
| EGF | Epidermal growth factor |
| EGR-1 | Early growth response 1 |
| ELK1 | ELK1, member of ETS oncogene family |
| ERBB2 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| ERK1 | Mitogen-activated protein kinase 3 |
| ERK2 | Mitogen-activated protein kinase 1 |
| EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit |
| FER | Fer (fps/fes related) tyrosine kinase |
| FHL2 | Four and a half LIM domains 2 |
| HDAC | Histone deacetylase 9 |
| IGF1 | Insulin-like growth factor 1 |
| IGF1R | Insulin-like growth factor 1 receptor |
| IL-6 | Interleukin 6 |
| IL-6R | Interleukin 6 receptor |
| JAK2 | Janus kinase 2 |
| JNK | Mitogen-activated protein kinase 8 |
| JNKK | Mitogen-activated protein kinase kinase 4 |
| KLK2 | Kallikrein-related peptidase 2 |
| MEK1 | Mitogen-activated protein kinase kinase 1 |
| MEK2 | Mitogen-activated protein kinase kinase 2 |
| MEKK | Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
| p300 | E1A binding protein p300 |
| p35 | Cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
| PAR4 | Prader Willi/Angelman region RNA 4 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase |
| PRKCE | Protein kinase C, epsilon |
| PSA | Prostate specific antigen |
| PTEN | Phosphatase and tensin homolog |
| PTP1B | Protein tyrosine phosphatase, non-receptor type 1 |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
| RAF | Raf-1 proto-oncogene, serine/threonine kinase |
| RAS | Harvey rat sarcoma viral oncogene homolog |
| RTK | Receptor Tyrosine Kinase |
| SRC-1 | Nuclear receptor coactivator 1 |
| STAT3 | Signal transducer and activator of transcription 3 |
| TMPRSS2 | Transmembrane protease, serine 2 |
| TRPV6 | Transient receptor potential cation channel, subfamily V, member 6 |
| VAV3 | Vav 3 guanine nucleotide exchange factor |
| YB-1 | Y box binding protein 1 |
| YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
| ZEB1 | Zinc finger E-box binding homeobox 1 |