Marmot p53  SSSVPSQNTYPGVYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSTPPP 151
       Rat p53  SSSVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPP 151
   Hamster p53  SSSVPSYKTFQGDYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVNSTPPP 153
       Cat p53  SSFVPSQKTYPGAYGFHLGFLQSGTAKSVTCTYSPPLNKLFCQLAKTCPVQLWVRSPPPP 145
 Zebrafish p53  TSTVPETSDYPGDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQ 121
   Xenopus p53  SCAVPSTDDYAGKYGLQLDFQQNGTAKSVTCTYSPELNKLFCQLAKTCPLLVRVESPPPR 127
     Human p53  SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPP 153
                ============================================================
     Human p53  SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPP 153

    Marmot p53  GTRVRAMAIYKKSQHMTEVVRRCPHHERCSDS-DGLAPPQHLIRVEGNLRAEYLDDRNTF 210
       Rat p53  GTRVRAMAIYKKSQHMTEVVRRCPHHERCSDG-DGLAPPQHLIRVEGNPYAEYLDDRQTF 210
   Hamster p53  GTRVRAMAIYKKLQYMTEVVRRCPHHERSSEG-DSLAPPQHLIRVEGNLHAEYLDDKQTF 212
       Cat p53  GTCVRAMAIYKKSEFMTEVVRRCPHHERCPDSSDGLAPPQHLIRVEGNLHAKYLDDRNTF 205
 Zebrafish p53  GSVVRATAIYKKSEHVAEVVRRCPHHERTPDG-DNLAPAGHLIRVEGNQRANYREDNITL 180
   Xenopus p53  GSILRATAVYKKSEHVAEVVKRCPHHERSVEPGEDAAPPSHLMRVEGNLQAYYMEDVNSG 187
     Human p53  GTRVRAMAIYKQSQHMTEVVRRCPHHERCSDS-DGLAPPQHLIRVEGNLRVEYLDDRNTF 212
                ============================================================
     Human p53  GTRVRAMAIYKQSQHMTEVVRRCPHHERCSDS-DGLAPPQHLIRVEGNLRVEYLDDRNTF 212

    Marmot p53  RHSVVVPYEPPEVGSECTTIHYNYMCNSSCMGGMNRRPILTIITLEGSSGNLLGRNSFEV 270
       Rat p53  RHSVVVPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEV 270
   Hamster p53  RHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEV 272
       Cat p53  RHSVVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPIITIITLEDSNGKLLGRNSFEV 265
 Zebrafish p53  RHSVFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEV 240
   Xenopus p53  RHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIITLETPQGLLLGRRCFEV 247
     Human p53  RHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEV 272
                ============================================================
     Human p53  RHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEV 272

    Marmot p53  RVCACPGRDRRTEEENF 287
       Rat p53  RVCACPGRDRRTEEENF 287 
   Hamster p53  RICACPGRDRRTEEKNF 289
       Cat p53  RVCACPGRDRRTEEENF 282
 Zebrafish p53  RVCACPGRDRKTEESNF 257
   Xenopus p53  RVCACPGRDRRTEEDNY 264
     Human p53  RVCACPGRDRRTEEENL 289
                ================= 
     Human p53  RVCACPGRDRRTEEENL 289

Sample output of COMBOSA3D showing a colored three-dimensional representation of p53 (Cho et al., 1994) binding to DNA. The colored reference alignment produced by COMBOSA3D is also given. Residues that are identical among the comparison sequences (the sequences located above the row of equal signs) are colored dark blue, while similar residues are colored light blue. Residues that are not identical or similar among 80% of the sequences are colored red.