OMIM :  162651

GENECARD : NTSR1

CGAP : 110642

• neurotensin receptor 1 (high affinity)
• NTR
• NTSR1

Clinical

• Presence of GI receptors may provide for targeted chemotherapy or radiation therapy. Ehlers RA, Kim S, Zhang Y, Ethridge RT, Murrilo C, Hellmich MR, Evans DB, Townsend CM Jr, Mark Evers B.

• NTR-1 mRNA could also be used as a specific diagnostic marker and treatment target in pancreatic cancer. Wang L, Friess H, Zhu Z, Graber H, Zimmermann A, Korc M, Reubi JC, Buchler MW.

Function

• Neurotensin (NT), a gastrointestinal (GI) hormone, binds its receptor (NTR) to stimulate proliferation of normal and neoplastic GI tissues. Ehlers RA, Zhang Y, Hellmich MR, Evers BM.

Regulation

• The enhanced expression of NTR-1 mRNA in pancreatic cancer cells further suggests that neuroendocrine hormones might modulate pancreas cancer cell behavior. Wang L, Friess H, Zhu Z, Graber H, Zimmermann A, Korc M, Reubi JC, Buchler MW.

Signaling pathway

• Expression of NTR, functionally coupled to the Ca2 signaling pathway, was identified in L3.6 cells. Ehlers RA, Kim S, Zhang Y, Ethridge RT, Murrilo C, Hellmich MR, Evans DB, Townsend CM Jr, Mark Evers B.