AKT1

AKT1

OMIM: 164730

GENECARD: AKT1

CGAP: 71816

SYNONYMS

v-akt murine thymoma viral oncogene homolog 1
PKB
RAC

Chromosome human

The AKT1 proto-oncogene maps to human chromosome 14, band q32. Staal SP, Huebner K, Croce CM, Parsa NZ, Testa JR.

Clinical

PI3K-PKB/Akt pathway plays a significant role in mediating drug resistance in human pancreatic cancer cells. Ng SSW, Tsao MS, Chow S, Hedley DW.

Homolgue

We demonstrate that Dictyostelium Akt/PKB, a homologue of mammalian Akt/PKB, is very rapidly and transiently activated by the chemoattractant cAMP. Meili R, Ellsworth C, Lee S, Reddy TB, Ma H, Firtel RA.

Protein structure

The predicted protein contains consensus sequences characteristic of a protein kinase catalytic domain and shows 73% and 68% similarity to protein kinase C and the cAMP-dependent protein kinase. Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA.

Function

We conclude that activation of the Akt1/PKBalpha pathway affects islet beta cell mass by alteration of size and number. Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA.

Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Liu H, Perlman H, Pagliari LJ, Pope RM.

Akt/PKB regulates laminin and collagen IV isotypes of the basement membrane. Li X, Talts U, Talts JF, Arman E, Ekblom P, Lonai P.

Regualtion

AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Tanno S, Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH, Testa JR.

RNA structure

Northern (RNA) analysis revealed a single mRNA transcript of 3.2 kilobases that varied up to 300-fold between different cell lines. Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA.

General

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME.