OMIM : 152391
GENECARD : ALOX12
CGAP : 1200
SYNONYMS
arachidonate 12-lipoxygenase
Clinical
Blockade of LOX enzymes may be valuable for the treatment of human pancreatic cancer. Ding XZ, Kuszynski CA, El-Metwally TH, Adrian TE.
Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. Ding XZ, Iversen P, Cluck MW, Knezetic JA, Adrian TE.
Function
Leukocyte type 12-lipoxygenase (12-LO) catalyzes the conversion of arachidonic acid (AA; C20:4) to 12-hydroperoxyeicosatetraenoic acid (12-HPETE) and linoleic acid (LA; C18:2) to 13-hydroperoxyoctadecadienoic acid (13-HPODE). Bleich D, Chen S, Gu JL, Nadler JL.
Oncogenicity
Both 5-LOX and 12-LOX expression is upregulated in human pancreatic cancer cells and LOX plays a critical role in pancreatic cancer cell proliferation. Ding XZ, Iversen P, Cluck MW, Knezetic JA, Adrian TE.