OMIM : 118440

GENECARD : CCK

CGAP : 80247

Chromosome human

• The genes for human gastrin and cholecystokinin are located on different chromosomes. Lund T, Geurts van Kessel AH, Haun S, Dixon JE.

• Structure of human cholecystokinin gene and its chromosomal location. Takahashi Y, Fukushige S, Murotsu T, Matsubara K.

Clinical

• Perspectives of CCK antagonists in pancreatic research and clinical use. Rovati LC.

DNA structure

• Structure of human cholecystokinin gene and its chromosomal location. Takahashi Y, Fukushige S, Murotsu T, Matsubara K.

Function

• Roles of gastrointestinal hormones in pancreatic cancer. Guo YS, Townsend CM Jr

Oncogenic Activation

• CCK may have a promotional effect on exocrine pancreatic cancer. Andren-Sandberg A, Hoem D, Backman PL.

• Cholecystokinin, secretin, bombesin, gastrin, EGF, TGF-alpha, insulin, and IGF-1 have a growth-promoting effect. Fisher WE, Muscarella P, Boros LG, Schirmer WJ.

• Cholecystokinin stimulates growth of human pancreatic adenocarcinoma SW-1990. Smith JP, Solomon TE, Bagheri S, Kramer S.

• In pancreas and prostate cancers serum CCK may follow tumour load and disease progression. Pichon MF, Coquin G, Fauveau C, Rey A.

Regulation

• Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway. Hirata M, Tsuchida A, Iwao T, Sasaki T, Matsubara K, Yamamoto S, Morinaka K, Kawasaki Y, Fujimoto Y, Inoue H, Kariya K, Kajiyama G.