OMIM :  118444

GENECARD : CCKAR

CGAP : 129

Chromosome human

• Using fluorescence in situ hybridization, we determined that CCKAR maps to 4p15.1-p15.2. Inoue H, Iannotti CA, Welling CM, Veile R, Donis-Keller H, Permutt MA

• The human CCKAR gene maps to chromosome 4. de Weerth A, Pisegna JR, Huppi K, Wank SA.

Clinical

• Clinical evaluation and safety of loxiglumide (CCK-A receptor antagonist) in nonresectable pancreatic cancer patients. Italian Pancreatic Cancer Study Group. Militello C, Sperti C, Di Prima F, Pedrazzoli S.

Function

• Transfected cholecystokinin receptors mediate growth inhibitory effects on human pancreatic cancer cell lines.etjen K, Fenrich MC, LogsdonCD.
  

Homologue

• Nucleotide sequence analysis revealed an open reading frame encoding a 428 amino acid protein, with seven putative transmembrane domains and a high degree of homology with the rat CCKA receptor. Ulrich CD, Ferber I, Holicky E, Hadac E, Buell G, Miller LJ.

• The gene encoding the CCKA receptor maps to a syntenic region of human chromosome 4 and mouse chromosome 5. Huppi K, Siwarski D, Pisegna JR, Wank S.

Oncogenic activation

• Other risk factors for pancreatic cancer: hormonal aspects. Andren-Sandberg A, Hoem D, Backman PL.

Oncogenicity

• Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer.Moonka R, Zhou W, Bell RH Jr.

Protein structure

• Nucleotide sequence analysis revealed an open reading frame encoding a 428 amino acid protein, with seven putative transmembrane domains and a high degree of homology with the rat CCKA receptor. Ulrich CD, Ferber I, Holicky E, Hadac E, Buell G, Miller LJ.

Regulation

• Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer.
  Moonka R, Zhou W, Bell RH Jr.
  

• A blockade of the CCK-A and CCK-B receptors by their antagonists led to an increased, an unaffected, or a decreased cell number of the cell lines. Ohlsson B, Fredang N, Axelson J.