OMIM :  120470

GENECARD : DCC

CGAP : 211567

Biochemical Type

• DCC gene encodes several related glycoprotein species. Reale MA, Hu G, Zafar AI, Getzenberg RH, Levine SM, Fearon ER.

• Immunohistochemical localization of deleted-in-colon-cancer (DCC) protein in human epithelial, neural, and neuro-endocrine tissues in paraffin sections with antigen retrieval. Hsu YH, Shaw CK, Chuong CM.

• Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. Reale MA, Hu G, Zafar AI, Getzenberg RH, Levine SM, Fearon ER.

Chromosome, Human

• A gene called deleted in colon cancer (DCC) has been identified on a region of chromosome 18. Hsu YH, Shaw CK, Chuong CM.

• The DCC gene located on chromosome 18q21.3. Hohne MW, Halatsch ME, Kahl GF, Weinel RJ.

Function

• The DCC gene located on chromosome 18q21.3 codes for a potential tumor suppressor gene related to cellular adhesion receptors. Hohne MW, Halatsch ME, Kahl GF, Weinel RJ.

• The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression. Barbera VM, Martin M, Marinoso L, Munne A, Carrato A, Real FX, Fabre M.

• Loss of DCC gene expression is an important factor in the development or progress of pancreatic adenocarcinoma. Hohne MW, Halatsch ME, Kahl GF, Weinel RJ.

Tumor Gene Type

• The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression. Barbera VM, Martin M, Marinoso L, Munne A, Carrato A, Real FX, Fabre M.

• Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Hohne MW, Halatsch ME, Kahl GF, Weinel RJ.