OMIM :  600997

GENECARD : EPHB2

CGAP : 125124

Clinical

• Smad4-independent phosphatase-mediated inhibition of mitogen-activated ERK2 represents a novel effector pathway contributing to suppression of epithelial pancreatic carcinoma cell proliferation by TGFbeta1. Giehl K, Seidel B, Gierschik P, Adler G, Menke A.

Function

• Ras-MEK-ERK-signaling cascade appears to be essential for mediating these effects of TGF-beta1.Ellenrieder V, Hendler SF, Boeck W, Seufferlein T, Menke A, Ruhland C, Adler G, Gress TM.

• Conditional activation of the Raf-MEK-ERK pathway in NIH 3T3 cells led to a 5 to 20-fold induction of cell surface alpha6- and beta3-integrin expression. Woods D, Cherwinski H, Venetsanakos E, Bhat A, Gysin S, Humbert M, Bray PF, Saylor VL, McMahon M.

• EGF receptor and the ERK MAP kinase pathway mediate autocrine signals. Murphy LO, Cluck MW, Lovas S, Otvos F, Murphy RF, Schally AV, Permert J, Larsson J, Knezetic JA, Adrian TE.

• Addition of neurotensin to PANC-1 cells induced extracellular-regulated protein kinase (ERK-1 and ERK-2) activation and subsequently, stimulated DNA synthesis. Ryder NM, Guha S, Hines OJ, Reber HA, Rozengurt E.

• TGFbeta1-induced growth inhibition is mediated by a Smad4-independent prevention of ERK2 activation. Giehl K, Seidel B, Gierschik P, Adler G, Menke A.

• MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. Boucher MJ, Morisset J, Vachon PH, Reed JC, Laine J, Rivard N.

• Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival. Paraskevas S, Aikin R, Maysinger D, Lakey JR, Cavanagh TJ, Hering B, Wang R, Rosenberg L.

Oncogenicity

• MEK/ERK and P38 MAP kinase interaction is important for pancreatic cancer cell proliferation. Ding XZ, Adrian TE.

Regulation

• MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1. Ding XZ, Adrian TE.

• Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2. Yip-Schneider MT, Lin A, Marshall MS.

Signaling Pathway

• MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. Boucher MJ, Morisset J, Vachon PH, Reed JC, Laine J, Rivard N.