OMIM : 164870

GENECARD : ERBB2

CGAP : 323910

Clinical

• HER-2/neu expression in pancreatic adenocarcinoma: relation to tumor differentiation and survival. Dugan MC, Dergham ST, Kucway R, Singh K, Biernat L, Du W, Vaitkevicius VK, Crissman JD, Sarkar FH.

• HER-2/Neu expression as a progression marker in pancreatic intraepithelial neoplasia. Tomaszewska R, Okon K, Nowak K, Stachura J.

• The immunohistochemical expressions of c-erbB-2 oncoprotein is useful in forming a prognosis for pancreatic cancer patients. Yamanaka Y.

Gene Frequency (Tumors)

• Immunohistochemical evaluation of HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas. Apple SK, Hecht JR, Lewin DN, Jahromi SA, Grody WW, Nieberg RK.

• Oncogenes in cancer of the pancreas. Sakorafas GH, Lazaris A, Tsiotou AG, Koullias G, Glinatsis MT, Golematis BC.

• Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms. Day JD, Digiuseppe JA, Yeo C, Lai-Goldman M, Anderson SM, Goodman SN, Kern SE, Hruban RH.

• HER-2/neu expression in pancreatic adenocarcinoma. Dugan MC, Dergham ST, Kucway R, Singh K, Biernat L, Du W, Vaitkevicius VK, Crissman JD, Sarkar FH.

Oncogenicity

• The c-erbB-2 overexpression in human pancreatic carcinoma cell lines may contribute to the carcinogenesis or progression of this cancer. Chen J, Liu TH.

• Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene. Evers BM, Rady PL, Sandoval K, Arany I, Tyring SK, Sanchez RL, Nealon WH, Townsend CM Jr, Thompson JC.

• Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms. Day JD, Digiuseppe JA, Yeo C, Lai-Goldman M, Anderson SM, Goodman SN, Kern SE, Hruban RH.

Tumor Gene Type

• Oncogenes in cancer of the pancreas. Sakorafas GH, Lazaris A, Tsiotou AG, Koullias G, Glinatsis MT, Golematis BC.

• Gastrinomas demonstrate amplification of the HER-2/neu proto-oncogene. Evers BM, Rady PL, Sandoval K, Arany I, Tyring SK, Sanchez RL, Nealon WH, Townsend CM Jr, Thompson JC.

• Oncogenes (K-ras and HER-2/neu) are mutated in a large proportion of adenocarcinoma of pancreas. Perugini RA, McDade TP, Vittimberga FJ Jr, Callery MP.

• The immunohistochemical expressions of c-erbB-2 oncoprotein in human pancreatic cancer. Yamanaka Y.

• The c-erb B-2 proto-oncogene in human pancreatic cancer. Hall PA, Hughes CM, Staddon SL, Richman PI, Gullick WJ, Lemoine NR.

Tumor Type

• The c-erbB-2 protooncogene has been shown to be overexpressed and/or amplified in carcinomas of the breast, ovary, pancreas, and other organs. Muller S, Vigneswaran N, Gansler T, Gramlich T, DeRose PB, Cohen C.