OMIM :  136350

GENECARD : FGFR1

CGAP : 748

• In the normal pancreas, acidic FGF, basic FGF, and FGFR-1 immunoreactivity was present at low to moderate levels in a heterogeneous pattern in the cytoplasm of acinar and ductal cells. Ebert M, Yokoyama M, Ishiwata T, Friess H, Buchler MW, Malfertheiner P, Korc M.

Cell Type Distribution

• Expression of the fibroblast growth factor receptor-1 in human normal tissues and tumors determined by a new monoclonal antibody. Morikawa Y, Ishihara Y, Tohya K, Kakudo K, Seo MK, Matsuura N.

• Aberrant expression of type I fibroblast growth factor receptor in human pancreatic adenocarcinomas. Kobrin MS, Yamanaka Y, Friess H, Lopez ME, Korc M.

• Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues. Hughes SE.

Clinical

• Inhibition of FGFR signaling may ultimately prove useful as a therapeutic option in patients with pancreatic cancer. Wagner M, Lopez ME, Cahn M, Korc M.

• FGFR 1, 2, and 3 have alternative splicing forms encoded by different exons for the C-terminal half of the third Ig-like domain. Takaishi S, Sawada M, Morita Y, Seno H, Fukuzawa H, Chiba T.

Function

• Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo. Wagner M, Lopez ME, Cahn M, Korc M.

• Fibroblast growth factor receptors (FGFRs) have been increasingly recognized to play an important role in the pathobiology of pancreatic malignancy. El-Hariry I, Pignatelli M, Lemoine NR.

• Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues. Hughes SE.

• Role of fibroblast growth factors and their receptors in pancreatic cancer and chronic pancreatitis. Kornmann M, Beger HG, Korc M.

Gene Frequency (Tumors)

• Molecular biology of pancreatic cancer: overexpression of fibroblast growth factors. Friess H, Korc M, Buchler MW.

Oncogenicity

• Role of fibroblast growth factors and their receptors in pancreatic cancer. Kornmann M, Beger HG, Korc M.

• Fibroblast growth factor receptors (FGFRs) have been increasingly recognized to play an important role in the pathobiology of pancreatic malignancy. El-Hariry I, Pignatelli M, Lemoine NR.

• Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo. Wagner M, Lopez ME, Cahn M, Korc M.

• FGFR-1 may play a role in the growth behavior of pancreatic cancer and may contribute to tumor aggressiveness. Friess H, Korc M, Buchler MW.

Tumor Type

• Expression of the fibroblast growth factor receptor-1 in human normal tissues and tumors determined by a new monoclonal antibody. Morikawa Y, Ishihara Y, Tohya K, Kakudo K, Seo MK, Matsuura N.