OMIM :  146930

GENECARD : IL8

CGAP : 624

DNA Structure

• The region from -85 to -133 bp was essential for the constitutive IL-8 promoter activity. Le X, Shi Q, Wang B, Xiong Q, Qian C, Peng Z, Li XC, Tang H, Abbruzzese JL, Xie K.

Function

• Interleukin-8 (IL-8), originally discovered as a chemotactic factor for leukocytes, has recently been shown to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. Xie K.

• IL-8 plays an important role in tumor angiogenesis and contributes to the aggressive biology of human pancreatic cancer. Le X, Shi Q, Wang B, Xiong Q, Qian C, Peng Z, Li XC, Tang H, Abbruzzese JL, Xie K.

• Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1. Takamori H, Oades ZG, Hoch OC, Burger M, Schraufstatter IU.

• IL-8 plays an important role in tumor angiogenesis and contributes significantly to the aggressive biology of human pancreatic cancer. Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, Xie K.

Oncogenicity

• Interleukin-8 (IL-8),has recently been shown to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. Xie K.

• Low tumor pH contributes to the enhanced expression of IL-8 and plays an important role in tumor progression. Shi Q, Le X, Wang B, Xiong Q, Abbruzzese JL, Xie K.

• IL-8 plays an important role in tumor angiogenesis and contributes to the aggressive biology of human pancreatic cancer. Le X, Shi Q, Wang B, Xiong Q, Qian C, Peng Z, Li XC, Tang H, Abbruzzese JL, Xie K.

• Effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells. Miyamoto M, Shimizu Y, Okada K, Kashii Y, Higuchi K, Watanabe A.

Protein Structure          

• Disulfide bridges in interleukin-8 probed using non-natural disulfide analogues. Rajarathnam K, Sykes BD, Dewald B, Baggiolini M, Clark-Lewis I.

Regulation

• Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma. Xiong Q, Shi Q, Le X, Wang B, Xie K.

• Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells. Shi Q, Le X, Wang B, Xiong Q, Abbruzzese JL, Xie K.

• Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. Le X, Shi Q, Wang B, Xiong Q, Qian C, Peng Z, Li XC, Tang H, Abbruzzese JL, Xie K.

• Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Andoh A, Takaya H, Saotome T, Shimada M, Hata K, Araki Y, Nakamura F, Shintani Y, Fujiyama Y, Bamba T.

• The expression of chemokine genes correlates with nuclear factor-kappaB activation in human pancreatic cancer cell lines. Takaya H, Andoh A, Shimada M, Hata K, Fujiyama Y, Bamba T.

• Hypoxia and acidosis contribute to the overexpression of IL-8. Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, Xie K.