Biochemical Type

• Transmembrane 4 superfamily as a prognostic factor in pancreatic cancer. Sho M, Adachi M, Taki T, Hashida H, Konishi T, Huang CL, Ikeda N, Nakajima Y, Kanehiro H, Hisanaga M, Nakano H, Miyake M.

Chromosome,Human

• KAI1 is located on chromosome 11p11.2-13. Guo X, Friess H, Graber HU, Kashiwagi M, Zimmermann A, Korc M, Buchler MW.

• Location of KAI1 on the short arm of human chromosome 11. Kawana Y, Komiya A, Ueda T, Nihei N, Kuramochi H, Suzuki H, Yatani R, Imai T, Dong JT, Imai T, Yoshie O, Barrett JC, Isaacs JT, Shimazaki J, Ito H, Ichikawa T.

DNA Structure

• Genomic organization of the human KAI1 metastasis-suppressor gene.Dong JT, Isaacs WB, Barrett JC, Isaacs JT.

Regulation

• Activation of the tumor metastasis suppressor gene, KAI1, by etoposide is mediated by p53 and c-Jun genes. Mashimo T, Bandyopadhyay S, Goodarzi G, Watabe M, Pai SK, Gross SC, Watabe K.

• Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines. Jackson P, Millar D, Kingsley E, Yardley G, Ow K, Clark S, Russell PJ.

Tumor Gene Type

• Reduced KAI1 expression associates with malignant progression of……White A, Lamb PW, Barrett JC.

• Role of KAI1 in the suppression of invasion.Geradts J, Maynard R, Birrer MJ, Hendricks D, Abbondanzo SL, Fong KM,Barrett JC, Lombardi DP.

• Reduction of KAI1 expression might enable pancreatic cancer cells to spread… Guo X, Friess H, Graber HU, Kashiwagi M, Zimmermann A, Korc M, Buchler MW.

• Reduced KAI1 expression in pancreatic cancer is associated with lymph node and distant metastases. Friess H, Guo XZ, Berberat P, Graber HU, Zimmermann A, Korc M, Buchler MW.