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Chromosome human
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The
encoding sequences for these proteins are organized in two gene
clusters, one at 18q21 (SMAD2, SMAD4, and SMAD7)…Jonson T, Gorunova
L, Dawiskiba S, Andren-Sandberg A, Stenman G, ten Dijke P, Johansson
B, Hoglund M.
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Function
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Phosphorylation
of Smad2/Smad3 by activated TbetaRI is inhibited by two newly
discovered members of the Smad family, Smad6 and Smad7.Kleeff J,
Ishiwata T, Maruyama H, Friess H, Truong P, Buchler MW, Falb D, Korc
M.
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Oncogenicity
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Smad7
mRNA levels are increased in human pancreatic cancer by comparison
with the normal pancreas. Kleeff J, Ishiwata T, Maruyama H, Friess H,
Truong P, Buchler MW, Falb D, Korc M.
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