OMIM :  600982

GENECARD : MAP3K1

CGAP : 298727

Cell cycle

• Activation of the ERK pathway functions to protect pancreatic tumor cells from apoptosis as well as to regulate their progression in the cell cycle. Boucher MJ, Morisset J, Vachon PH, Reed JC, Laine J, Rivard N.

Function

• Activation of the ERK pathway functions to protect pancreatic tumor cells from apoptosis as well as to regulate their progression in the cell cycle. Boucher MJ, Morisset J, Vachon PH, Reed JC, Laine J, Rivard N.

• The activation of the 41-/43-kDa MAP kinases was accompanied by the activation of Raf-1 in the majority of tumor cells and was completely associated with the activation of MEK and p90rsk in all the tumor cells examined. Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O,  Shimada Y,  Ari-i S, Wada H, Fujimoto J, Kohno M.

• Activation of the MAPK cascade is essential for the hPLA2-I-induced MIAPaCa-2 proliferation. Kinoshita E, Handa N, Hanada K, Kajiyama G, Sugiyama M.

• MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski  M, Yao Z.

Oncogenicity

• MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. Boucher MJ, Morisset J, Vachon PH, Reed JC, Laine J, Rivard N.

• Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Giehl K, Skripczynski B, Mansard A, Menke A, Gierschik P.

Regulation

• MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1. Ding XZ, Adrian TE.

• Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Giehl K, Skripczynski B, Mansard A, Menke A, Gierschik P.