OMIM :  164785

GENECARD : MDM2

CGAP : 170027

Function

• MDM2 gene can abrogate the cell growth arrest mediated by wild type p53 and the antagonistic function of wild type p53. Guo H, Liu T, Gao J.

Tumor gene type

• ARF binds the MDM2 proto-oncogene and stabilizes p53. Robertson KD, Jones PA.

• Expression and amplification of MDM2 oncogene. Guo H, Liu T, Gao J.