OMIM :  164860

GENECARD : MET

CGAP : 285754

Cell Type Distribution

• Evidence for HGF and c-Met expression early in all human fetal digestive tissues. Kermorgant S, Walker F, Hormi K, Dessirier V, Lewin MJ, Lehy T.

• Expression of hepatocyte growth factor and its receptor, C-Met in human digestive tissues and different gastric and colonic cancer cell lines. Kermorgant S, Cadiot G, Lewin MJ, Lehy T.

• The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Prat M, Narsimhan RP, Crepaldi T, Nicotra MR, Natali PG, Comoglio PM.

• Mild MET immunoreactivity in acinar, ductal, and islet cells in the normal human pancreas and intense MET immunoreactivity in many of the duct-like cancer cells. Ebert M, Yokoyama M, Friess H, Buchler MW, Korc M.

DNA Structure

• Gene structure of the human MET proto-oncogene. Duh FM, Scherer SW, Tsui LC, Lerman MI, Zbar B, Schmidt L.

Function

• Malignant transformation of human pancreatic duct cells commonly results in a deregulation of expression of various growth factors and receptors. Liu N, Furukawa T, Kobari M, Tsao MS.

• Strongly increased HGF receptor expression in pancreatic carcinoma. Kiehne K, Herzig KH, Folsch UR.

• Developmental expression and functionality of hepatocyte growth factor and c-Met in human fetal digestive tissues. Kermorgant S, Walker F, Hormi K, Dessirier V, Lewin MJ, Lehy T.

• A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Otonkoski T, Cirulli V, Beattie M, Mally MI, Soto G, Rubin JS, Hayek A.

• Hepatocyte growth factor (HGF) and its receptor c-Met exert mitogene and motogene activities in digestive tissues. Kermorgant S, Cadiot G, Lewin MJ, Lehy T.

• Met/HGF receptor may be involved in the growth and behavior of pancreatic cancer and may contribute to the ductal phenotype of these tumors. Di Renzo MF, Poulsom R, Olivero M, Comoglio PM, Lemoine NR.

• The receptor encoded by c-MET plays a physiological role in epithelial cell growth and that its expression is altered in human carcinomas. Prat M, Narsimhan RP, Crepaldi T, Nicotra MR, Natali PG, Comoglio PM.

Oncogenicity

• Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer. Ebert M, Yokoyama M, Friess H, Buchler MW, Korc M.

Regulation

• Growth factors (EGF, TGF-alpha, HGF) and growth factor receptors (EGF-R, c-met, CCK) are expressed at levels not found in the normal pancreas. Perugini RA, McDade TP, Vittimberga FJ Jr, Callery MP.

• C-met protooncogene expression and its regulation by cytokines in the regenerating pancreas and in pancreatic cancer cells. Otte JM, Kiehne K, Schmitz F, Folsch UR, Herzig KH.

• C-MET is up-regulated in the majority of pancreatic ductal adenocarcinomas. Di Renzo MF, Poulsom R, Olivero M, Comoglio PM, Lemoine NR.

Tumor Gene Type

• Gene structure of the human MET proto-oncogene. Duh FM, Scherer SW, Tsui LC, Lerman MI, Zbar B, Schmidt L.

• Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Di Renzo MF, Poulsom R, Olivero M, Comoglio PM, Lemoine NR.