OMIM :  120360

GENECARD : MMP2

CGAP : 111301

Biochemical type

• Basement membrane degradation is a critical component of tumor invasion and metastasis that is facilitated by the family of enzymes known as matrix metalloproteinases (MMPs). MMP-2 and MMP-9 are two subtypes. Zervos EE, Shafii AE, Rosemurgy AS.

• MMP-2, 72-kDa gelatinase/type IV collagenase. Fujimoto N, Mouri N, Iwata K, Ohuchi E, Okada Y, Hayakawa T.

Clinical

• Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment. Zucker S, Cao J, Chen WT.

• Matrix metalloproteinase inhibition improves survival in an orthotopic model of human pancreatic cancer. Zervox EE, Franz MG, Salhab KF,  Shafii AE, Menendez J, Gower WR, Rosemurgy AS.

• Matrix metalloproteinases (MMPs) play an important role in tissue remodeling under normal physiological and pathological conditions and are thus attractive targets for both diagnostic and therapeutic purposes. Gingras D, Renaud A, Mousseau N, Beaulieu E, Kachra Z, Beliveau R.

• Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma. Kuniyasu H, Ellis LM, Evans DB, Abbruzzese JL, Fenoglio CJ, Bucana CD, Cleary KR, Tahara E, Fidler IJ.

Function

• MMP-2 and MT1-MMP are required in breaking down basement membrane barriers in the early stage of angiogenesis. Zucker S, Cao J, Chen WT.

• TGF-beta-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2. Ellenrieder V, Hendler SF, Ruhland C, Boeck W, Adler G, Gress TM.

• Role of MT-MMPs and MMP-2 in pancreatic cancer progression. Ellenrieder V, Alber B, Lacher U, Hendler SF, Menke A, Boeck W, Wagner M, Wilda M, Friess H, Buchler M, Adler G, Gress TM.

Oncogenicity

• MMP-2 and MMP-9, are thought to play major roles in pancreatic cancer growth and metastasis. Haq M, Shaeii AE, Zervos EE, Rosemurgy AS.

• MMP-2 expression correlated with degree of tumor cell Invasiveness. Yang X, Staren ED, Howard JM, Iwamura T, Bartsch JE, Appert HE.

• MMP-2 and -13 are involved in the neoangiogenic and focal clonal selection and expansion phenomena associated with in situ tumor progression, invasion of the microvasculature, and metastasis. Bodey B, Bodey B Jr, Siegel SE, Kaiser HE.

• Involvement of matrix metalloproteinase-2 activity in invasion and metastasis of pancreatic carcinoma. Koshiba T, Hosotani R, Wada M, Miyamoto Y, Fujimoto K, Lee JU, Doi R, Arii S, Imamura M.

• Expression of the activated form of MMP-2 may be specific to pancreatic cancer. Koshiba T, Hosotani R, Wada M, Fujimoto K, Lee JU, Doi R, Arii S, Imamura M.

• MMP2, MMP3 and TIMP1 in the invasive phenotype of pancreatic and ampullary cancer. Bramhall SR, Stamp GW, Dunn J, Lemoine NR,  Neoptolemos JP.

• In human pancreatic cancer, MMP-2, MMP-9, TIMP-1 and TIMP-2 may be involved in processes leading to the strong desmoplastic reaction. Gress TM, Muller-Pillasch F, Lerch MM, Friess H, Buchler M, Adler G.

Protein size      

• MMP-2 (72-kDa collagenase IV). Gress TM, Muller-Pillasch F, Lerch MM, Friess H, Buchler M, Adler G.

• A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelatinase/type IV collagenase) using monoclonal antibodies. Fujimoto N, Mouri N, Iwata K, Ohuchi E, Okada Y, Hayakawa T.

Regulation

• Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-beta1 and MMPs. Zhang H, Morisaki T, Matsunaga H, Sato N, Uchiyama A, Hashizume K, Nagumo F, Tadano J, Katano M.

• MT1-MMP is involved in the progression of pancreatic cancer via activation of MMP-2. Ellenrieder V, Alber B, Lacher U, Hendler SF, Menke A, Boeck W, Wagner M, Wilda M, Friess H, Buchler M, Adler G, Gress TM.