OMIM :  158340


CGAP : 89603




  • mucin 1, transmembrane
  • PUM



Biochemical type



  • Mucins are high molecular weight glycoproteins having oligosaccharides attached to the apomucin protein backbone by O-glycosidic linkages. Yonezawa S, Sato E.


  • MUC 1 is a type I transmembrane protein with a large number of tandem repeat consisting of 20 amino acids. Hinoda Y, Imai K.



Cell location



Cell type distribution







  • The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma. Luttges J, Zamboni G, Longnecker D, Kloppel G.



  • Mucins in the diagnosis and therapy of pancreatic cancer. Ho JJ.




  • Adoptive immunotherapy for pancreatic cancer, using MUC1 specific CTL. Masaki Y, Oka M.



  • New mucin core protein genes and their clinical application. Imai K.



  • Serological pancreatic tumor markers and the MUC1 apomucin. Ho JJ, Kim YS.


  • Cytokeratins and mucins as molecular markers of cell differentiation and neoplastic transformation in the exocrine pancreas. Vila MR, Balague C, Real FX.


  • Molecular biological analyses of mucin core proteins and their clinical. Application. Hinoda Y, Imai K.








DNA Structure





  • The carbohydrates of mucins on the surface of tumor cells have been reported to inhibit cells of the immune system. These carbohydrates also act as ligands during the process of tumor cell metastasis. Ho JJ.








Gene Frequencey (tumor)



Ligand Binding

  • Mucins of the human pancreatic cancer cell line, SW1990, have both sialyl-Lewis(a) and sialyl-Lewis(x) carbohydrate ligands that are implicated in tumor cell metastasis. Ho JJ, Siddiki B, Kim YS.


  • Muc 1 is associated with several of the serological pancreatic cancer carbohydrate markers, including CA19-9.Ho JJ, Kim YS.






  • Expression of mucin antigens in human cancers and its relationship with malignancy potential. Yonezawa S, Sato E.



Protein Structure       


  • MUC1 is a type I transmembrane protein with a large number of tandem repeat consisting of 20 amino acids. Imai K.





  • sialic acids play an important role in determining the net negative charge of sialyl-Lewis(a) and sialyl-Lewis(x) rich mucins and in obscuring MUC1 peptide regions. Ho JJ, Siddiki B, Kim YS.




Tumor incidence

  • In intraductal papillary-mucinous neoplasm (IPMN) of the pancreas (n = 9), MUC1, MUC2, MUC3, and MUC5/6 apomucins were expressed in 8/9 (89 percent), 0/9 (0 per cent), 4/9 (44 per cent), and 9/9 (100 per cent) case, respectively. Terada T, Ohta T, Sasaki M, Nakanuma Y, Kim YS.