OMIM :  134637

GENECARD : TNFRSF6

CGAP : 82359

Chromosome human

• The human APO-1 (APT) antigen maps to 10q23. Lichter P, Walczak H, Weitz S, Behrmann I, Krammer PH.

• Assignment of the human Fas antigen gene (Fas) to 10q24.1. Inazawa J, Itoh N, Abe T, Nagata S.

Clinical

• Tumor escape mechanisms may contribute to the poor prognosis of pancreatic cancer but also represent targets for new treatment modalities. UngefrorenH, Voss M, Bernstorff WV, Schmid A, KremerB, Kalthoff H.

• Prognostic significance of molecular alterations in human pancreatic carcinoma--an immunohistological study. Gansauge F, Gansauge S, Schmidt E, Muller J, Beger HG.
  

Function

• As in other types of stress-induced apoptosis, the CD95/CD95L system is one of the different routes to suicide optionally used by hyposmotically stressed cells. Jackle T, Hasel C, Melzner I, Bruderlein S, Jehle PM, Moller P.

• CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells. Trauzold A, Wermann H, Arlt A, Schutze S, Schafer H, Oestern S, Roder C, Ungefroren H, Lampe E, Heinrich M, Walczak H, Kalthoff H.

• Production and pro-apoptotic activity of soluble CD95 ligand in pancreatic carcinoma.
  Bellone G, Smirne C, Carbone A, Mareschi K, Dughera L, Farina EC, Alabiso O, Valente G, Emanuelli G, Rodeck U.

• Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids. Lepple-Wienhues A, Belka C, Laun T, Jekle A, Walter B, Wieland U, Welz M, Heil L, Kun J, Busch G, Weller M, Bamberg M, Gulbins E, Lang F.

• Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Nagata S,GolsteinP.

• The Fas-associated phosphatase-1 is a strong candidate to confer Fas resistance in pancreatic cancer cells. Ungefroren H, Voss M, Bernstorff WV, Schmid A, Kremer B, Kalthoff H.

• Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis. Ungefroren H, Voss M, Jansen M, Roeder C, Henne-Bruns D, Kremer B, Kalthoff H.

• CD95-related apoptotic machinery is functional in pancreatic cancer cells. Glazyrin AL, Adsay VN, Vaitkevicius VK, Sarkar FH.

Protein structure

• Molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide (Mr 36,000) with a single transmembrane domain. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S.

Regulation

• Pancreatic cancer cells have functional CD95-related apoptotic machinery with preserved apoptotic signal transduction, CD95R upregulation. and caspase  activation. GlazyrinAL, Adsay VN, VaitkeviciusVK,Sarkar FH.

Signal transduction

• Pancreatic cancer cells have functional CD95-related apoptotic machinery with preserved apoptotic signal transduction, CD95R upregulation. and caspase  activation. GlazyrinAL, Adsay VN, VaitkeviciusVK,Sarkar FH.