[BiO BB] gene regulatory network reconstruction and pathway finding from the micro-array data
Li Fan
hustlf at cs.cmu.edu
Sun Aug 3 17:27:06 EDT 2003
Hi,
I am a graduate student in CS dept. I am dointg some work in learning
gene regulatory network from the
micro-array data. On major problem I am facing is that it is very hard
to evaluate the results.
For example, I have runned experiments on 6211 yeast genes and my
experimental results suggest that gene
YBR231C is "directly " connected with
YAR014C YBR261C YBR237W YBR215W YBL111C YER138C YBR169C
YAR073W YBL064C YBR022W YCR093W YBR025C YDR180W
YCR040W YGL130W
YBR213W YBR160W
(sorted according to descending probability score)
However, it is hard to judge to what extent the program has succeeded. I
know Nir Friedman has done a
fundamental experiment
http://www.cs.huji.ac.il/labs/compbio/expression/. But it is still
difficult to give
a direct comparisan because Friedman's experiment is only on the 800 cell
cycle genes, not on the all 6000 genes.
Further more, only few edges are listed with comments from biologists in
that paper.
So could somebody give me some suggestions about the benchmark which can
be used to evaluate the success
of the bayes network structure learning algorithm(which is used to learn
the genetic structure)?
Thanks a lot
Fan Li
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