[BiO BB] a validation study

l x yi lxyiwc at yahoo.com
Mon Dec 6 17:29:25 EST 2004

I have developed a new method for searching protein
banks with PSSM (position-specific matrices). To do a
validation analysis of the method on real protein
sequences, I need to decide 

-- a selection of some position-specific matrices for
major protein domains
-- a databank of single sequences
-- a gold standard of which sequences truly belonged
to which protein domain

Could anyone suggest some reliable sources of
references as to how to conduct this validation
analysis? Any suggestions are appreciated. 


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