[BiO BB] protein clustering threshold

[Shamshad Zarina]

Thanks, Iddo. This might be the example Hongyu is
looking for.

Shamshad
--- Iddo Friedberg <idoerg at burnham.org> wrote:
> Shamshad:
> 
> Turkey delta-crystallin has a 90% ID w/
> argininosuccinate lyase. See:
> 
> NATURE Structural Biology, vol.1, No.10, Pp724-733,
> October, 1994 
> A.Simpson,  et al.
> `The structure of avian eye lens delta crystallin
> reveals a new fold for 
> a superfamily of oligomeric enzymes'
> 
> 
> Iddo
> 
> Shamshad Zarina wrote:
> > Crystallins are very good examples for proteins
> having
> > structural and sequence similarity but different
> > functions. I work on lens protiens but I don't
> recall
> > an example with >90% identity yet different
> functions.
> > 
> > 
> > One example with less identity is of
> Rho-crystallin
> > found in bull-frog where it acts as 'structural
> > protein' to maintain lens transparency. It shows
> 55%
> > sequence identity with Aldo-keto reductase
> superfamily
> > which are enzymes. Both proteins have similar
> three
> > dimensioanl structure and one residue required for
> > catalytic activity is absent in rho-crystallin.
> > 
> > Best,
> > Shamshad 
> > 
> > --- Iddo Friedberg <idoerg at burnham.org> wrote:
> > 
> >>Not to answer your question directly, 
> >>just to add confusion:
> >>
> >>How about the same protein which performs
> different
> >>functions?
> >>Crystallins
> >>are an example of a protease which, in the eye
> lens,
> >>serves as a
> >>transparent buffer.
> >>
> >>There are other such "moonlighting proteins" look
> >>at:
> >>
> > 
> >
>
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12902157&dopt=Abstract
> > 
> >>./I
> >>
> >>--
> >>Iddo Friedberg, Ph.D.
> >>The Burnham Institute
> >>10901 N. Torrey Pines Rd.
> >>La Jolla, CA 92037, USA
> >>Tel: +1 (858) 646 3100 x3516
> >>Fax: +1 (858) 646 3171
> >>http://ffas.ljcrf.edu/~iddo
> >>
> >>On Fri, 6 Feb 2004, Hongyu Zhang wrote:
> >>
> >>
> >>>Does anyone have examples of two proteins with
> >>>90%
> >>>identity have differenct functions? I need it as
> a
> >>>proof to cluster a protein sequence library.
> >>>
> >>>Thanks!
> >>>
> >>>Hongyu
> >>>
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> 
> -- 
> Iddo Friedberg, Ph.D.
> The Burnham Institute
> 10901 N. Torrey Pines Rd.
> La Jolla, CA 92037
> USA
> Tel: +1 (858) 646 3100 x3516
> Fax: +1 (858) 713 9930
> http://ffas.ljcrf.edu/~iddo
> 
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