[BiO BB] Is there a good way to find orthologue sequences?

[Dr. Christoph Gille]

There is always the danger of picking a paralogous sequence instead.
If two genes are orthologous then the sequence identity should be
typical for the two species.
If they are paralogous the sequence identiy is higher.
I am not convinced that this can be solved completely automatically.

Christoph




> Dear all,
> Is there a good way to find orthologue sequences? I mean, I have a
> protein sequence in species A, how could I get all the available
> corresponding sequences from other species?  I blast my sequence to nr,
> there are just too many hits with low e-value and high identity, so that
> some "corresponding" sequences from distant related species could not be
> find by blast. Is there any good method for automatically solve this
> problem?
>
> Thank you very much.
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