[BiO BB] Native Conformation vs Minimum Energy
boris.steipe at utoronto.ca
Thu Jul 13 15:55:07 EDT 2006
If that were the case, one would need to have a large enough energy
barrier between the native state and the minimum energy state AND one
would need to specify the folding pathway kinetically (the native
state is reached faster than the minimum), rather than
thermodynamically (the native state is the minimum and all folding
trajectories ultimately find it).
No, we don't believe this is the way it works in general since this
would require specifying and maintaining information in a sequence
that is not actually useful. But exceptions are of course "possible",
even though to my knowledge none have been rigorously demonstrated.
(The example of a protein that folds as a pro-protein but is
functional after cleaving the pro-sequence comes close though).
On 13-Jul-06, at 1:11 PM, Pooja Jain wrote:
> Dear All,
> Is it possible that the biological active native state of a protein
> need not to
> be of lowest free energy ?
> Bioinformatics.Org general forum -
> BiO_Bulletin_Board at bioinformatics.org
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