[BiO BB] Reactome 19 released
Reactome-Knowledgebase at reactome.org
Reactome-Knowledgebase at reactome.org
Fri Nov 17 11:02:41 EST 2006
The Reactome Knowledgebase team (Lincoln Stein's group at CSHL and
Ewan Birney's group at European Bioinformatics Institute) is proud
to announce the release of Reactome Version 19, accessible at
http://www.reactome.org!
Reactome is a curated knowledgebase of biological processes in
humans. It covers processes ranging from basic pathways of metabolism
to complex events such as hormonal signaling and apoptosis. The
information in Reactome is provided by expert bench biologists, and
edited and managed as a relational database by the Reactome staff.
New material is peer-reviewed and revised as necessary before
publication to the web. Reactome entries are linked to corresponding
ones in NCBI, Entrez Gene, RefSeq, OMIM, Ensembl genome annotations,
UCSC Genome Browser, KEGG, ChEBI and Gene Ontology (GO). Two way
links between HapMap and Reactome have been enabled from this release.
Version 19 marks the completion of "Early phase of HIV life cycle"
with the release of Uncoating, Reverse Transcription and Integration
under HIV Life Cycle. Other new modules include HIV Vpu protein
interactions with host and Transport of Influenza virus RNPs into
host nucleus under host pathogen interactions, signaling cascades
mediated by Toll-like receptors 5,7/8,9-11, and cell cycle events
mediated by p27/p21 proteins.
The standard display feature allows the user to choose the focus
species annotations - curated (for human) and electronically inferred
(for 22 other species). A feature for version tracking using stable
identifiers has been enabled. Updated release statistics and the
Editorial Calendar are available. As before, Reactome data can be
exported in SMBL, Protégé, and BioPAX level 2 formats.
Like everything in Reactome, these downloaded and exported materials
can be reused and redistributed freely. For questions and comments
please reply to this message or write to help at reactome.org
-Gopal Gopinathrao
Reactome, CSHL
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