[BiO BB] For Workshop: Need Proteins with known struct and mutations

[Bioinformatics World Wide]

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Regards




> For our Workshop next week we would like to ask you for your ideas about
> proteins with known 3D-structure, and known disease causing mutations.
>
> Next week we will give a practical workshop in Bioinformatics for
> postgraduate students of Molecular Medicine.
>
> Our plan is that each student chooses a protein.  The students will
> obtain all mutations and SNPs from the literature and from databases.
>
> The students should then visualize the mutations on a homologous
> 3D-structure using the Pymol view (http://en.wikipedia.org/wiki/Pymol)
> integrated in STRAP ( http://3d-alignment.eu/ ).
>
> In the final presentation each student should discuss the function of
> his/her protein and how the mutation could affect its function in terms of
> catalysis, ligand binding, 3D-structure stability ... .
>
> Do you have ideas for proteins that would be appropriate?
>
> Many thanks
>
> Christoph
>
>
>
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