I've been reading the biocluster list for some time but since we have been, mainly, satisfied with our setup I have not jumped in. Now I have a question. Background: We have $40K of "end of year" money needing to be spent soon; a single 3700 sequencer pumping out ~200 sequences a day; and a pair of Sun E-450 (4 GB memory, 4 processor) servers providing GCG/Emboss, database and local Blast support when needed. Many of our current Blast searches are batched to NCBI but occasionally we run searches against non-standard datasets. Such processing can take over the Sun computers for a couple of days. What off-the-shelf biocluster would you recommend? I would prefer not to build a system from scratch and would also prefer not to spend too much time installing and maintaining Linux and Blast itself although "rolling our own" on the software end is more feasible than the hardware end. We would also want to run HMMer and perhaps some other data-intensive software on the cluster. I have looked at RLX, RackSaver, and the Paracel offerings. Any other leads? Thank you for any advice, -- Rick Rick Westerman firstname.lastname@example.org Phone: (765) 494-0505 FAX: (765) 496-7255 S049 WSLR bldg. Purdue Univ. W. Lafayette, IN 47907-1153 Bioinformatics specialist at the Genomics Facility. href="http://www.biochem.purdue.edu/~westerm"