I've had a lot of conversations lately where blast has been discussed in the past tense. However I am yet to hear of its replacement. Is there a clear leader for the replacement of blast? If so is it parallelisable? Does it still use the fasta format datasets? Gavin Gavin Kennedy Software Engineer - Bioinformatics CSIRO Mathematical and Information Sciences Gavin.Kennedy@CSIRO.AU ph: 612-6246-4929