Hi folks: I have had the joy of playing with an Opteron for a few days, and have done some preliminary testing on it using some BLAST runs. Hopefully I will be able to summarize in a few days. One of the interesting side effects of working on this platform is the need to update one of the NCBI header files. Here is my quick diff: diff ./ncbi/include/ncbilcl.h.original ./ncbi/include/ncbilcl.h 90a91,92 > #elif defined(__x86_64__) || #cpu(x86_64) || #machine(x86_64) > #define PROC_X86_64 Without this, it does compile, but it complains about not knowing which processor it was being compiled for. Hopefully I can get longer term access to an Opteron along with better compilers, so I can complete this work. Just an FYI. Joe -- Joseph Landman, Ph.D Scalable Informatics LLC, email: landman@scalableinformatics.com web : http://scalableinformatics.com phone: +1 734 612 4615