The mpiBLAST development team is pleased to announce the availability of mpiBLAST 1.2.0. New features in this release include: * Alignments are output for translated searches. * Incremental database updates. * Distributed sequence lookup during output formatting. * Commandline options now match the latest version of NCBI-BLAST. * Scripts are provided to interface mpiBLAST with the NCBI web front end via the PBS scheduling system. mpiBLAST is a parallelization of NCBI BLAST that replaces formatdb and blastall with versions that use MPI to execute in parallel on a cluster of computers. There are two primary advantages to using mpiBLAST versus traditional BLAST. First, mpiBLAST splits the database across each node in the cluster. Because each node's segment of the database is smaller it can usually reside in the buffer-cache, yielding a significant speedup due to the reduction of costly disk I/O. Second, because interprocessor communication demands are low, BLAST users can efficiently use low-cost Beowulf clusters . Source code for both Unix and Windows is freely available at http://mpiblast.lanl.gov Please direct questions and bug reports to the sourceforge discussion board at http://sourceforge.net/projects/mpiblast