Folks: We have been doing more testing on Opterons. This time a 246 unit. For the particular NCBI BLAST job we are using (blastx of 74 sequences vs nr from July, will happily supply both the database and the test scripts to anyone in exchange for their results and machine details), the dual Opteron is showing an execution time with 2 threads giving the best results, and the Xeon 3 GHz system showing best results with 4 threads (odd, HT must be working). What we are seeing is that comparing the best efforts of these two platforms, using the binary suitable with gcc on both platforms, that the 246 completes the run in 586 seconds, while the Xeon completes it in 1006 seconds. These are wall clock seconds, as measured by the start and end times of the script. Note: We are trying to work with the Intel compiler as well to see if it helps. We are using sse2 on gcc, and m64 mode on the Opteron. We are also seeing some interesting affinity bits. It looks like we need a way to pin memories and CPUs together for scheduling for best performance. Has anyone successfully built the NCBI toolkit using the ICC? If so, would you be willing to share your linux.ncbi.mk file? Thanks! Joe -- Joseph Landman, Ph.D Scalable Informatics LLC email: landman@scalableinformatics.com web: http://scalableinformatics.com phone: +1 734 612 4615