Hi folks, I work on file systems and am doing some research into NFS issues when running Blast. I have read a number of posts on the bioclusters mailing list regarding usage of local disks being better. However, after reading the mpiBlast white paper, I got the impression that mpiBlast would avoid nfs read io after the server caches are warmed up. (Of course as long as the data fits in the server memory pool). So I guess i am a little curious as to whether people still feel nfs is not suited for mpiBlast and if so, why ? Do you have multiple databases against which searches are performed (so that the cache is purged periodically ?). Or does the database not fit into the combined memory of a typical cluster ? thanks in advance for your response, Joydeep __________________________________ Do you Yahoo!? Yahoo! SiteBuilder - Free web site building tool. Try it! http://webhosting.yahoo.com/ps/sb/