Sharon, I am another person that has never installed MPI blast, so I can't help you with your specific problem. If you are interested in running your search on the TimeLogic DeCypher hardware accelerated BLAST system, please contact me in a private e-mail message. Normally, I would send a private e-mail message to you, but I see Tristan's message, checked with some other biocluster members, and decided to give you this information on the list. -Alan -- - Alan Kilian <alank(at)timelogic.com> Director of Bioinformatics, TimeLogic Corporation 763-449-7622