If anyone is running 100% BLAST, HMMs or Profiles, and is interested in hearing about a hardware accelerated version of these types of searches, please contact me. We have a single PCI card that is approximately 500-1000 Sparc CPUs worth of HMM performance. Solaris or Windows OS compatible. Please contact me in private e-mail, or we can discuss the cluster-compatible offerings from TimeLogic on the list. I'd be happy to provide benchmark reports on various types of searches if people are interested in this type of thing. I understand that this is a bioCLUSTER mailing list, so if people don't want to get involved in this type of solution, I understand completely. -Alan -- - Alan Kilian <alank(at)timelogic.com> Director of Bioinformatics, TimeLogic Corporation 763-449-7622