Hi, we are looking at a quad-cpu server for our bioinformatics apps like multithreaded clustalw, blast and some in-house multithreaded application I developed over time. I noticed that I can get a basic 8GB RAM 4xOpteron 848 with a RAID controller and a couple of hdds for close to $17,000. At the same time it looks like I can get a 4xXeon MP 2.7Ghz with the same ram/hdd configuration for close to the same price. Any insights on the performance of the Opteron quad boxes? How do they compare to their 32-bit counterparts like Xeon MPs? Have they proven suitable for your bioinformatics environment? Any advice would be valuable! Thanks, Ognen -- Ognen Duzlevski Digital Biology Laboratory 302 North Engineering Building University of Missouri-Columbia (573) 882-5978