(sorry for spamming) Scalable Informatics has released Scalable HMMer, an optimized version of HMMer 2.3.2 that is 1.6-2.5x faster on benchmark tests run on Opteron systems. Please see http://www.scalableinformatics.com for details on where to download it, and how to use the yum repository. Joe -- Joseph Landman, Ph.D Founder and CEO Scalable Informatics LLC, email: landman at scalableinformatics.com web : http://www.scalableinformatics.com phone: +1 734 786 8423 fax : +1 734 786 8452 cell : +1 734 612 4615