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<P><FONT face=Verdana><STRONG><FONT size=4><FONT size=3><FONT
color=#ff0000>REGISTRATION DEADLINE FRIDAY - </FONT><FONT color=#000000>Register
Today for Only </FONT></FONT></FONT></STRONG><STRONG><FONT
color=#000000>$1095 Commercial, $545 Academic/Government!</FONT></STRONG>
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</FONT><STRONG><FONT size=+0><FONT color=#800040><FONT face=Verdana><FONT
size=4>10th Annual </FONT><BR></FONT></FONT></FONT><FONT face=Verdana
color=#800040 size=6>Cheminformatics <BR></FONT></STRONG><FONT
face=Verdana><FONT color=#800040 size=4>Applying Informatics Tools to Solve
Discovery Chemistry Problems</FONT>
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May 23-24, 2006 | Pennsylvania Convention Center| Philadelphia, PA<BR><BR>*
<STRONG>Registration Deadline This Friday -</STRONG> Register Today
at:<BR> </FONT><A href="https://commerce22.datapipe.com/chidb/2006/wpc/reg.asp"><FONT
face=Verdana
color=#0000ff>https://commerce22.datapipe.com/chidb/2006/wpc/reg.asp</FONT></A><BR><BR><FONT
face=Verdana>* </FONT><FONT face=Verdana><STRONG>Download a PDF of this Brochure
at: <BR></STRONG> </FONT><A
href="http://www.worldpharmacongress.com/pdfdownload06_cin.asp"><FONT
face=Verdana>www.worldpharmacongress.com/pdfdownload06_cin.asp</FONT></A><BR><BR><FONT
face=Verdana>* <STRONG>View Conference Website
at:</STRONG><BR> </FONT><A
href="http://www.worldpharmacongress.com/06_cin.asp"><FONT face=Verdana
color=#0000ff>http://www.worldpharmacongress.com/06_cin.asp</FONT></A><BR><BR><FONT
face=Verdana>* </FONT><FONT face=Verdana><STRONG>Additional Ways To
Save!<BR></STRONG> - Register with a Poster and Save an Additional
$50. <BR> - Reserve a Room at the Lowes
Philadelphia Hotel <BR> and Save an Additional
$50.<BR> <BR>* </FONT><FONT face=Verdana><FONT color=#000000>A
Must Attend Conference for Researchers and Leaders
in <EM><STRONG>Informatics</STRONG></EM><BR>
and <STRONG><EM>Computational Chemistry</EM></STRONG></FONT>
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</FONT><STRONG><FONT face=Verdana>Featured Sessions and
Speakers<BR><BR></FONT></STRONG><FONT color=#000000><FONT color=#800040><FONT
size=2><STRONG><FONT color=#ff0000><B><FONT face=Verdana color=#000000
size=4><U>Integration of Informatics and Knowledge Management
Informatics</U></FONT></B>
<P></P>
<P><FONT face=Verdana>Spot Lecture<BR></FONT></FONT><FONT face=Verdana
color=#000000>Integration of Informatics at the Systems Level and at the Data
Level</FONT></STRONG><BR><FONT face=Verdana><FONT color=#000000>Chris L. Waller,
Ph.D., Director, World Wide Chemistry Informatics, Pfizer Global Research &
Development</FONT> </FONT></FONT><BR><BR></FONT><STRONG><FONT face=Verdana
size=2>Integrated Knowledge Management at Bayer HealthCare: Pharmacophore
Informatics <BR></FONT></STRONG><FONT face=Verdana><I><FONT size=2>William
J. Scott, Ph.D., Team Leader, Department for Chemistry Research, Bayer
Pharmaceuticals Corporation</FONT><BR></I><BR></FONT><STRONG><FONT face=Verdana
size=2>Building a Knowledge Enabled Organization<BR></FONT></STRONG><FONT
face=Verdana><I><FONT size=2>Cory R. Brouwer, Ph.D., Associate Director,
Knowledge Management Informatics, Pfizer Global Research &
Development</FONT><BR></I><BR></FONT><STRONG><FONT face=Verdana size=2>Knowledge
Management: Building a Knowledge Enabled Organization<BR></FONT></STRONG><FONT
face=Verdana><I><FONT size=2>Victor Lobanov, Ph.D., Principal Scientist, MDI,
Johnson & Johnson Pharmaceutical R&D</FONT><BR></I><BR></FONT><FONT
face=Verdana><FONT size=2><STRONG><FONT size=4><U>Old Dogs New Tricks Technical
Session</U><BR></FONT><BR>Chairperson:</STRONG> <EM>Michael S. Lajiness, Ph.D.,
Research Scientist, Structural & Computation Sciences, Eli Lilly &
Co.</EM></FONT><BR><BR><STRONG>Panelists Include:</STRONG><BR><BR></FONT><FONT
face=Verdana><FONT color=#408080><EM><FONT color=#000000><FONT size=2>Dimitris
K. Agrafiotis, Ph.D., Senior Research Fellow, Johnson & Johnson
Pharmaceutical Research & Development, LLC<BR><BR>Gus Rosania, Ph.D.,
Professor, Pharmaceutical Sciences, University of Michigan<BR></FONT><BR><FONT
size=2>Jeffrey S. Wiseman, Ph.D., Vice President and Officer, Technology and
Informatics, Locus Pharmaceuticals </FONT><BR><BR><FONT size=2>Jim Wikel,
Ph.D., Chief Technology Officer, Coalesix
Inc.</FONT></FONT><BR></EM></FONT><BR><B><FONT color=#000000 size=4><U>QSAR -
Practical Approaches</U></FONT></B></FONT></P>
<P><FONT face=Verdana><STRONG><FONT size=2>Practical Tweaks for
QSAR</FONT></STRONG><BR><EM><FONT size=2>Robert P. Sheridan, Ph.D., Senior
Investigator, Molecular Systems, Merck Research
Labs</FONT></EM><BR><BR></FONT><FONT face=Verdana><FONT size=2><STRONG>Extending
Linearity for QSAR: Nonlinear Regression Approaches That Still Maintain the
Intuitive Character of Linear Models<BR></STRONG><I>Peter Buchwald, Ph.D.,
Associate Director of Drug Discovery, IVAX Research,
Inc</I></FONT><BR><BR></FONT><STRONG><FONT face=Verdana size=2>Reverse
Fingerprinting and Fingerprint Bit Importance<BR></FONT></STRONG><FONT
face=Verdana><I><FONT size=2>Chris I. Williams, Ph.D., Principle Scientist,
Chemical Computing Group</FONT><BR></I><BR><B><FONT color=#000000
size=4><U>Predicting ADMET, Targets & MOA</U></FONT></B></FONT></P>
<P><FONT face=Verdana><FONT size=2><STRONG>Robust Computational Framework for
Predictive ADME-Tox Modeling <BR></STRONG><I>Alex Tropsha, Ph.D.,
Department of Pharmacology, School of Medicine, University of North Carolina,
Chapel Hill, North Carolina</I></FONT><BR><BR></FONT><FONT size=2><STRONG><FONT
face=Verdana>Identification of Chemical Address Tags Controlling the Subcellular
Distribution of Candidate Drugs and Bioimaging
Probes<BR></FONT></STRONG><EM><FONT face=Verdana>Gus Rosania, Professor,
Pharmaceutical Sciences, University of Michigan<BR><BR></FONT></EM><STRONG><FONT
face=Verdana>Mining Chemogenomics Databases to Predict Novel Ligand-Target
Pairings<BR></FONT></STRONG><EM><FONT face=Verdana>Jeremy Jenkins, Ph.D.,
Research Investigator, Lead Discovery Center, Novartis Institutes for BioMedical
Research<BR></FONT></EM></FONT><BR><STRONG><FONT face=Verdana
color=#ff0000>RoundTable Buzz Sessions:</FONT></STRONG></P>
<P><FONT size=2><FONT face=Verdana><STRONG>Knowledge Management Systems -
Informatics Integration<BR>Moderator:</STRONG> <I>Cory Brouwer, Ph.D., Associate
Director, KM Informatics, Pfizer Inc.</I> <BR><BR></FONT><FONT
face=Verdana><STRONG>Hit-to-Lead - Choosing the Best Computational
Approaches<BR>Moderator:</STRONG> </FONT><EM><FONT face=Verdana>Jun Xu, Ph.D.,
Director of CADD, Integrated Drug Discovery, DPI<BR><BR></FONT></EM><B><FONT
color=#000000 size=4><FONT face=Verdana><U>The Growing Role for Informatics in
Hit-to-Lead and Lead Optimization</U> </FONT></FONT><FONT
size=2><BR></FONT></B></FONT><BR><STRONG><FONT face=Verdana size=2>Docking and
Scoring Methods for Lead Optimization; New Algorithms and Models for Improving
Binding Affinity Prediction<BR></FONT></STRONG><EM><FONT face=Verdana><FONT
size=2>Richard A. Friesner, Ph.D., Professor of Chemistry, Columbia
University</FONT><BR><BR></FONT></EM><FONT size=2><STRONG><FONT
face=Verdana>Getting to the Clinic Fast: Navigating Lead Optimization Pathways
by In Silico Tools<BR></FONT></STRONG><EM><FONT face=Verdana>Oren M. Becker,
Ph.D., Founder & Chief Scientific Officer, Predix
Pharmaceuticals <BR><BR></FONT></EM><STRONG><FONT face=Verdana>Large-Scale
Virtual Screening on a Computational Grid for Inhibitor Discovery at Texas
A&M<BR></FONT></STRONG><FONT face=Verdana><EM>James C. Sacchettini, Ph.D.,
Professor of Biochemistry & Biophysics, Biochemistry & Biophysics
Department, Texas A&M University<BR><BR></EM><STRONG>Panel: Lead
Optimization Informatics </STRONG><FONT color=#231f20><EM>Moderator: Oren M.
Becker, Ph.D.</EM></FONT></FONT></FONT></P>
<P><FONT face=Verdana></FONT></P><FONT face=Verdana>
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<STRONG>Plus Attend this Recommended Short Course:
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</STRONG><FONT size=2><FONT color=#804040 size=4><STRONG><FONT
color=#800040>Breakthrough Strategies for Text Mining in
R&</FONT>D</STRONG></FONT><BR><BR>Competition in the pharmaceutical industry
has increasingly become based upon better recognition and analysis of
information, much of which is available as published text. The days of
specialists being able to read all of the relevant literature coming out is long
past, particularly as more system biology approaches are used. New text-mining
tools are providing advantages for faster recognition and correlation of pieces
of information useful for creating a new hypothesis or asking new
questions. </FONT></FONT>
<P></P>
<UL>
<LI><FONT face=Verdana><FONT size=2>This tutorial will focus on ways to
explore progress in applying these new tools within drug discovery. It will
consist of an overview of new developments and methodologies and then focus on
two specific case studies of how two large companies have addressed the issue
in their organizations. </FONT> </FONT>
<LI><FONT face=Verdana size=2>Identifying a pattern to help explain an adverse
event </FONT></LI></UL>
<P><FONT face=Verdana size=2><STRONG>Presenters include:</STRONG></FONT></P>
<P><EM><FONT face=Verdana size=2>Jeremy Packer, Ph.D., Head of Bioinformatics,
Abbott Laboratories<BR><BR>Sherri Matis, Ph.D., Principal Informatics Scientist,
Discovery Informatics, AstraZeneca</FONT></EM></FONT><FONT face=Verdana>
</FONT></P><FONT face=Verdana>
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</FONT><STRONG><FONT face=Verdana>Hear These Keynotes
Presentations:<BR><BR></FONT></STRONG>
<DIV><STRONG><FONT face=Verdana>Plenary Keynotes:</FONT></STRONG><STRONG><FONT
face=Verdana> <BR></FONT></STRONG><FONT size=+0><FONT color=#000000><FONT
size=1><FONT size=3><FONT size=1><BR></FONT></FONT></FONT><FONT size=1><FONT
face=Verdana size=3><STRONG>Closing the Gap Between Research and the
Clinic - Biomarkers and Translational Medicine
Strategies</STRONG></FONT></FONT></FONT></FONT></DIV>
<DIV><FONT size=+0><FONT color=#000000><FONT size=1><FONT size=3><FONT
face=Verdana><FONT size=2>Orest Hurko, MD, Assistant Vice President,
Translational Research, Wyeth Research</FONT><BR><BR></FONT><FONT size=2><FONT
face=Verdana><STRONG>Investing in the Future - The Pharmaceutical and
Biotech Industry's Key Roadblocks<BR></STRONG>Steve Burrill, Chief Executive
Officer, Burrill and Co.<BR><BR><STRONG>Improving R&D By Addressing
Bottlenecks in NCEs & MBEs in the Drug Discovery Process</STRONG> <EM><FONT
size=1>(tentative title)</FONT></EM><BR>Mikael Dolsten, Ph.D., MD, Executive
Vice President, Corporate Division Pharma<BR>Research, Boehringer Ingelheim
Pharmaceuticals, Inc.</FONT></FONT></FONT></FONT></FONT></FONT><STRONG><FONT
face=Verdana>
<HR id=undefined>
</FONT></STRONG><FONT size=1><FONT size=2><FONT size=+0><FONT color=#000000
size=2><EM><FONT size=2><STRONG><FONT face=Verdana>"Cheminformatics meetings
gave a rare opportunity to quickly understand what is currently going on in this
ever dynamic field."</FONT></STRONG>
<P><FONT face=Verdana>Dharmesh Manitar<BR>Aston
Univeristy</FONT></FONT></EM></FONT></FONT><BR></FONT></FONT><FONT
face=Verdana>-----------------------------------------------------------------------<BR></FONT><FONT
size=4><FONT size=3><FONT size=4><FONT face=Verdana><FONT size=2>For Sponsorship
and Exhibit Information please contact <BR>Suzanne Carroll at 617-630-1352
or</FONT><FONT size=3> </FONT></FONT><A href="mailto:scarroll@healthtech.com"><FONT face=Verdana color=#0000ff
size=2>scarroll@healthtech.com</FONT></A><BR><FONT face=Verdana><FONT
size=3>------------------------------------------------------------------------</FONT><BR></FONT><STRONG><FONT
color=#004080><FONT face=Verdana color=#800040>The Tenth Annual Cheminformatics
Conference </FONT><FONT face=Verdana color=#000000 size=2>is part
of <BR></FONT></FONT></STRONG></FONT><STRONG><FONT face=Verdana>the World
Pharmaceutical Congress </FONT></STRONG></FONT></FONT></P></DIV>
<P><STRONG><FONT size=4><FONT face=Verdana><FONT size=3>For more details on this
event visit:</FONT><BR></FONT></FONT></STRONG><A
href="http://www.WorldPharmaCongress.com"><FONT face=Verdana color=#0000ff
size=4><STRONG>www.WorldPharmaCongress.com</STRONG></FONT></A><BR><BR><BR><FONT
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