<html><div style='background-color:'><P>Hello All,</P>
<P>I need a simple , freely downloadable , Clustering program , that will cluster a large number of records (>10,000) using Hierarchical Clustering Methods, and using Single Linkage Clustering Technique. </P>
<P>I would like to cluster a large number of proteins based on a similarity score that will be used as input and to output a tree in the form of a text file.</P>
<P>This program needs to be run from command line, prefereably a C executable from a UNIX machine. The input would be a text file of a distance matrix and the output will also be a text file of clusters or dendrograms.</P>
<P>I came across OC - Geoffery Barton - University of Dundee, that fits my required description, however the output is just a PS file, and thus cannot be manipulated further.</P>
<P>I also came across Eisen Lab's - CLuster3.0 , however, this is more complicated and used for mostly microarray data, since the input and output file fits the requirement for microarray sets.</P>
<P>Could someone please suggest me a simple program that would fit my description required? Would really appreciate it.</P>
<P>Thank you.</P>
<P>Shalini Sridhar</P>
<P>MRes.Bioinformatics and Computational Biology, Univ of Leeds,Leeds.<BR></P></div></html>