Frieda Reichsman wrote: > Dear Colleagues, > > I am seeking pdb files to use as paired examples of the effects of a > single amino acid substitution on protein structure/function. Ideally > I would like to have some examples of substitutions that alter > function, and some that have little or no evident functional effect. > If both types of substitutions are available for the same protein, so > much the better. > > A good example is normal and sickle cell hemoglobin, but I would like > to have somewhere between four and ten different protein examples. I > need some that affect binding or enzymatic activity and are located in > the binding or active site. > > Thanks in advance for suggestions on this topic. > > Frieda > > Frieda Reichsman, PhD > Molecules in Motion > Interactive Molecular Structures > www.moleculesinmotion.com > > MyDNA Project > www.bio.umass.edu/biochem/mydna > > _______________________________________________ > Molvis-list mailing list > Molvis-list at bioinformatics.org > https://bioinformatics.org/mailman/listinfo/molvis-list > What about ras and ras mutated in cancer cells? A single aminoacid change provokes that ras get always activated and with GTP bound to the "active center"