History of PyAnnHyb program:
============================

2011-03-30 v. 0.020:
- added window to select oligonucleotide to align
- fixed bug on alignment of oligonucleotides on short sequence


2011-03-09 v. 0.019:
- fixed bug on saving project without file extension

2011-01-18 v. 0.018:

- add "close project" function
- fixed bug for downloaded sequence annotation
- add "crop" and "delete" functions for sequence
- add window to select sequences for oligonucleotide alignment

2011-01-06 v. 0.017:

- add control of sequence name to prevent duplicate (for oligos and sequences)


2010-12-11: v. 0.017

- modified features management
- added revert complement tool
- added "New sequence" function
 

2009-08-05 v. 0.016:

- added molecular weight, molar extinction coefficient and checksum to Oligo tab
- added context menu to "Oligonucleotide Sequence" line edit (right-click on oligo sequence) allowing to:
 * group oligo sequence every 3 nucleotide
 * ungroup oligo sequence
 * switch oligo sequence to upper or lower case
- added features as tree view items (with colored background)
- added option for removing all oligo or all sequences (select oligo list / sequences list)
- added sequence checksum preference between SEGUID and GCG
- pyAnnHyb accepts now a project file as argument to command-line  

2009-07-27: v. 0.015

- improved the nearest-neighbour algorithm to allow degenerated oligonucleotides.
In case of degenerated oligonucleotides the Tm function returns minimum and maximum melting temperatures.

2009-07-??: v. 0.014

- added local alignment algorithm allowing to align oligonucleotides with sequences.
Alignments that are checked in the results window are added to sequence annotations and visualized on sequence with a red gradient
(increasing with alignment score)

2009-07-07: v. 0.013

- added "Annotations list" window that allow to modify/delete an annotation
- Oligo and sequences lists are now read-only

2009-07-06: v. 0.012
- fixed problem with monospace font under Windows and Mac OSX

2009-06-28: v. 0.010
- added "Map results" to restriction analysis tool

2009-06-12: ver. 0.009
- annotations/features are now saved in project file
- back-compatibility with Annhyb projects broken
- added translation tool
- added "Open sequence" function. Formats recognized: EMBL, GenBank, FASTA
- added "Save sequence" function. Formats allowed: GenBank, FASTA, HTML
- changed checksum function from GCG checksum to SEGUID checksum

2008-11: ver. 0.007
- removed dependency to configobj module
- added restriction analysis
- added color selection for regions highlighting

2008-10-31: ver. 0.005
- Introduced new dependencies:
    * biopython (deb package: python-biopython)
    * configobj (deb package: python-configobj)

-New features:
    * Retrieve sequence from NCBI server
    * Highlight sequence regions
        Limitations:
         - yellow color only
         - highlighted regions are not saved in project file

2008-10-23: ver. 0.004

2008-09-18: ver. 0.003

2008-07-23: ver. 0.002

2008-07-23: release of first PyAnnHyb version (ver. 0.001)