Basic Information
Gene ID 174341
Gene Name efl-3; CELE_F49E12.6, F49E12.6
Full Name Protein EFL-3
Organism Caenorhabditis elegans [6239]

Cross Reference
UniProt Q20619 UniGene Cel.17364
PDB NULL OMIM NULL
KEGG cel:CELE_F49E12.6 UCSC F49E12.6

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING 6239.F49E12.6

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
F49E12.6 Gene3D G3DSA:1.10.10.10 IPR011991 253 344 4.10e-14 Winged helix-turn-helix DNA-binding domain
F49E12.6 Gene3D G3DSA:1.10.10.10 IPR011991 93 166 2.40e-21 Winged helix-turn-helix DNA-binding domain
F49E12.6 PANTHER PTHR12081 IPR015633 18 598 0.00e-00 E2F Family
F49E12.6 Pfam PF02319 IPR003316 258 327 5.90e-12 Transcription factor E2F/dimerisation partner (TDP)
F49E12.6 Pfam PF02319 IPR003316 95 164 7.90e-21 Transcription factor E2F/dimerisation partner (TDP)

Pfam Annotation
Protein Pfam ID E.value Name Description
F49E12.6 PF02319 1.4e-35 E2F_TDP E2F/DP family winged-helix DNA-binding domain

Gene Ontology Annotation
Protein Entry Name Space Description
F49E12.6 GO:0000122 biological_process negative regulation of transcription from RNA polymerase II promoter
F49E12.6 GO:0001890 biological_process placenta development
F49E12.6 GO:0002040 biological_process sprouting angiogenesis
F49E12.6 GO:0006351 biological_process transcription, DNA-templated
F49E12.6 GO:0032466 biological_process negative regulation of cytokinesis
F49E12.6 GO:0032877 biological_process positive regulation of DNA endoreduplication
F49E12.6 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
F49E12.6 GO:0060707 biological_process trophoblast giant cell differentiation
F49E12.6 GO:0060718 biological_process chorionic trophoblast cell differentiation
F49E12.6 GO:0070365 biological_process hepatocyte differentiation
F49E12.6 GO:0005634 cellular_component nucleus
F49E12.6 GO:0005667 cellular_component transcription factor complex
F49E12.6 GO:0001047 molecular_function core promoter binding
F49E12.6 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
F49E12.6 GO:0003714 molecular_function transcription corepressor activity

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus 100399945 9601 Pongo abelii 100442584
9646 Ailuropoda melanoleuca 100467959 9785 Loxodonta africana 100673054
10029 Cricetulus griseus 100762445 7668 Strongylocentrotus purpuratus 100891325
30611 Otolemur garnettii 100958652 9597 Pan paniscus 100994943
9555 Papio anubis 101015748 39432 Saimiri boliviensis 101032517
9685 Felis catus 101085053 9595 Gorilla gorilla 101132000
9669 Mustela putorius furo 101688360 59463 Myotis lucifugus 102432485
10090 Mus musculus 108961 9606 Homo sapiens 144455
9478 Tarsius syrichta ENSTSYG00000007279 9615 Canis familiaris 482575
28377 Anolis carolinensis ENSACAG00000015743 9913 Bos taurus ENSBTAG00000016931
9358 Choloepus hoffmanni ENSCHOG00000006322 7719 Ciona intestinalis ENSCING00000014484
10141 Cavia porcellus ENSCPOG00000013766 9361 Dasypus novemcinctus ENSDNOG00000001580
10020 Dipodomys ordii ENSDORG00000003404 9796 Equus caballus ENSECAG00000017963
9365 Erinaceus europaeus ENSEEUG00000011472 9371 Echinops telfairi ENSETEG00000014750
9031 Gallus gallus ENSGALG00000004023 8049 Gadus morhua ENSGMOG00000019253
7897 Latimeria chalumnae ENSLACG00000016113 9315 Macropus eugenii ENSMEUG00000008461
9103 Meleagris gallopavo ENSMGAG00000002303 9544 Macaca mulatta ENSMMUG00000010853
13616 Monodelphis domestica ENSMODG00000020465 61853 Nomascus leucogenys ENSNLEG00000004897
9258 Ornithorhynchus anatinus ENSOANG00000011290 9986 Oryctolagus cuniculus ENSOCUG00000004932
9978 Ochotona princeps ENSOPRG00000001896 8090 Oryzias latipes ENSORLG00000000786
9813 Procavia capensis ENSPCAG00000000596 7757 Petromyzon marinus ENSPMAG00000001858
13735 Pelodiscus sinensis ENSPSIG00000008707 132908 Pteropus vampyrus ENSPVAG00000000288
10116 Rattus norvegicus ENSRNOG00000026252 42254 Sorex araneus ENSSARG00000004122
9305 Sarcophilus harrisii ENSSHAG00000018372 43179 Ictidomys tridecemlineatus ENSSTOG00000007887
37347 Tupaia belangeri ENSTBEG00000005417 59729 Taeniopygia guttata ENSTGUG00000015857
99883 Tetraodon nigroviridis ENSTNIG00000009615 9739 Tursiops truncatus ENSTTRG00000000110
30538 Vicugna pacos ENSVPAG00000011151 8364 Xenopus tropicalis ENSXETG00000004436
8083 Xiphophorus maculatus ENSXMAG00000010237