Basic Information
Gene ID 21410 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Hnf1b; Hnf-1b, Tcf2
Full Name Hepatocyte nuclear factor 1-beta
Organism Mus musculus [10090]

Cross Reference
UniProt P27889 UniGene Mm.7226
PDB NULL OMIM NULL
KEGG mmu:21410 UCSC uc007kpx.1

Protein Interactions
DIP NULL
IntAct P27889
MINT MINT-4097641
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMUSP00000021016 Gene3D G3DSA:1.10.10.60 IPR009057 235 310 3.60e-38 Homeodomain-like
ENSMUSP00000021016 Gene3D G3DSA:1.10.260.40 IPR010982 92 185 8.60e-44 Lambda repressor-like, DNA-binding domain
ENSMUSP00000021016 Pfam PF00046 IPR001356 232 305 4.50e-06 Homeobox domain
ENSMUSP00000021016 Pfam PF04812 IPR006897 314 552 2.10e-106 Hepatocyte nuclear factor 1, beta isoform, C-terminal
ENSMUSP00000021016 Pfam PF04814 IPR006899 1 182 6.40e-83 Hepatocyte nuclear factor 1, N-terminal
ENSMUSP00000021016 ProSiteProfiles PS50071 IPR001356 229 310 0.00e-00 Homeobox domain
ENSMUSP00000021016 SMART SM00389 IPR001356 231 314 1.10e-10 Homeobox domain
ENSMUSP00000021016 SUPERFAMILY SSF100957 IPR023219 1 32 0.00e-00 Hepatocyte nuclear factor 1, dimerisation domain
ENSMUSP00000021016 SUPERFAMILY SSF46689 IPR009057 223 318 0.00e-00 Homeodomain-like
ENSMUSP00000021016 SUPERFAMILY SSF47413 IPR010982 94 184 0.00e-00 Lambda repressor-like, DNA-binding domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMUSP00000021016 PF04812 0 HNF-1B_C Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
ENSMUSP00000021016 PF04814 0 HNF-1_N Hepatocyte nuclear factor 1 (HNF-1), N terminus
ENSMUSP00000021016 PF00046 1.6e-06 Homeobox Homeobox domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMUSP00000021016 GO:0006351 biological_process transcription, DNA-templated
ENSMUSP00000021016 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSMUSP00000021016 GO:0005634 cellular_component nucleus
ENSMUSP00000021016 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSMUSP00000021016 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
10029 Cricetulus griseus 100771619 9305 Sarcophilus harrisii 100934366
9595 Gorilla gorilla 101129879 43179 Ictidomys tridecemlineatus 101969172
7897 Latimeria chalumnae 102349678 9796 Equus caballus 100057769
9597 Pan paniscus 100982758 9555 Papio anubis 101013182
39432 Saimiri boliviensis 101030001 9669 Mustela putorius furo 101678534
13735 Pelodiscus sinensis 102451872 9615 Canis familiaris 610402
9544 Macaca mulatta 714540 28377 Anolis carolinensis ENSACAG00000006458
9646 Ailuropoda melanoleuca ENSAMEG00000013125 9358 Choloepus hoffmanni ENSCHOG00000006010
9483 Callithrix jacchus ENSCJAG00000015174 10141 Cavia porcellus ENSCPOG00000001234
7955 Danio rerio ENSDARG00000022295 10020 Dipodomys ordii ENSDORG00000009669
9371 Echinops telfairi ENSETEG00000019192 9685 Felis catus ENSFCAG00000000241
69293 Gasterosteus aculeatus ENSGACG00000011101 9031 Gallus gallus ENSGALG00000005504
9785 Loxodonta africana ENSLAFG00000002573 9103 Meleagris gallopavo ENSMGAG00000008126
30608 Microcebus murinus ENSMICG00000001274 59463 Myotis lucifugus ENSMLUG00000012260
13616 Monodelphis domestica ENSMODG00000019108 61853 Nomascus leucogenys ENSNLEG00000002919
30611 Otolemur garnettii ENSOGAG00000000869 9813 Procavia capensis ENSPCAG00000008147
7757 Petromyzon marinus ENSPMAG00000001209 10116 Rattus norvegicus ENSRNOG00000002598
42254 Sorex araneus ENSSARG00000007152 9823 Sus scrofa ENSSSCG00000022417
37347 Tupaia belangeri ENSTBEG00000007107 59729 Taeniopygia guttata ENSTGUG00000008342
99883 Tetraodon nigroviridis ENSTNIG00000016225 31033 Takifugu rubripes ENSTRUG00000003809
9478 Tarsius syrichta ENSTSYG00000010701 9739 Tursiops truncatus ENSTTRG00000015910
8083 Xiphophorus maculatus ENSXMAG00000011775 8364 Xenopus tropicalis 733490
9365 Erinaceus europaeus ENSEEUG00000004998 8049 Gadus morhua ENSGMOG00000016065
9315 Macropus eugenii ENSMEUG00000004443 9258 Ornithorhynchus anatinus ENSOANG00000007132
8128 Oreochromis niloticus ENSONIG00000013161 9978 Ochotona princeps ENSOPRG00000003933
8090 Oryzias latipes ENSORLG00000004564 132908 Pteropus vampyrus ENSPVAG00000010466
30538 Vicugna pacos ENSVPAG00000001980