Basic Information
Gene ID 7849 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name PAX8
Full Name Paired box protein Pax-8
Organism Homo sapiens [9606]

Cross Reference
UniProt Q06710 UniGene Hs.469728
PDB 2K27 OMIM 218700
KEGG hsa:7849 UCSC uc010yxu.2

Protein Interactions
DIP NULL
IntAct Q06710
MINT NULL
STRING 9606.ENSP00000395498

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000395498 Gene3D G3DSA:1.10.10.10 IPR011991 12 77 6.00e-40 Winged helix-turn-helix DNA-binding domain
ENSP00000395498 Gene3D G3DSA:1.10.10.10 IPR011991 78 138 2.50e-36 Winged helix-turn-helix DNA-binding domain
ENSP00000395498 Pfam PF00292 IPR001523 9 133 4.10e-71 Paired domain
ENSP00000395498 Pfam PF12403 IPR022130 339 449 1.50e-50 Paired-box protein 2 C-terminal
ENSP00000395498 PRINTS PR00027 IPR001523 13 28 3.70e-43 Paired domain
ENSP00000395498 PRINTS PR00027 IPR001523 31 49 3.70e-43 Paired domain
ENSP00000395498 PRINTS PR00027 IPR001523 51 68 3.70e-43 Paired domain
ENSP00000395498 PRINTS PR00027 IPR001523 69 86 3.70e-43 Paired domain
ENSP00000395498 ProSitePatterns PS00034 IPR001523 43 59 - Paired domain
ENSP00000395498 ProSiteProfiles PS51057 IPR001523 9 135 0.00e-00 Paired domain
ENSP00000395498 SMART SM00351 IPR001523 9 133 1.00e-95 Paired domain
ENSP00000395498 SUPERFAMILY SSF46689 IPR009057 11 133 0.00e-00 Homeodomain-like

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000395498 PF00292 0 PAX 'Paired box' domain
ENSP00000395498 PF12403 0 Pax2_C Paired-box protein 2 C terminal
ENSP00000395498 PF13384 0.00013 HTH_23 Homeodomain-like domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000395498 GO:0006351 biological_process transcription, DNA-templated
ENSP00000395498 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000395498 GO:0007275 biological_process multicellular organismal development
ENSP00000395498 GO:0045893 biological_process positive regulation of transcription, DNA-templated
ENSP00000395498 GO:0048793 biological_process pronephros development
ENSP00000395498 GO:2000611 biological_process positive regulation of thyroid hormone generation
ENSP00000395498 GO:0005634 cellular_component nucleus
ENSP00000395498 GO:0003677 molecular_function DNA binding
ENSP00000395498 GO:0044212 molecular_function transcription regulatory region DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9555 Papio anubis 101026378 39432 Saimiri boliviensis 101036832
9595 Gorilla gorilla 101137174 9615 Canis familiaris 403927
8128 Oreochromis niloticus 100701954 9597 Pan paniscus 100988818
9544 Macaca mulatta 701906 9913 Bos taurus ENSBTAG00000019354
10141 Cavia porcellus ENSCPOG00000012011 10020 Dipodomys ordii ENSDORG00000002606
69293 Gasterosteus aculeatus ENSGACG00000016747 9103 Meleagris gallopavo ENSMGAG00000007277
30608 Microcebus murinus ENSMICG00000003265 9669 Mustela putorius furo ENSMPUG00000009512
9986 Oryctolagus cuniculus ENSOCUG00000004187 8090 Oryzias latipes ENSORLG00000007225
9813 Procavia capensis ENSPCAG00000005498 9598 Pan troglodytes ENSPTRG00000012380
42254 Sorex araneus ENSSARG00000014324 9305 Sarcophilus harrisii ENSSHAG00000011845
9823 Sus scrofa ENSSSCG00000021332 43179 Ictidomys tridecemlineatus ENSSTOG00000024664
31033 Takifugu rubripes ENSTRUG00000018667 9739 Tursiops truncatus ENSTTRG00000011948
30538 Vicugna pacos ENSVPAG00000003973 8083 Xiphophorus maculatus ENSXMAG00000005467
9646 Ailuropoda melanoleuca ENSAMEG00000010662 9483 Callithrix jacchus ENSCJAG00000013889
7955 Danio rerio ENSDARG00000015879 9796 Equus caballus ENSECAG00000009244
9685 Felis catus ENSFCAG00000009580 9031 Gallus gallus ENSGALG00000005689
8049 Gadus morhua ENSGMOG00000011083 7897 Latimeria chalumnae ENSLACG00000003762
9785 Loxodonta africana ENSLAFG00000021590 9315 Macropus eugenii ENSMEUG00000013983
59463 Myotis lucifugus ENSMLUG00000011936 13616 Monodelphis domestica ENSMODG00000013770
61853 Nomascus leucogenys ENSNLEG00000002157 9258 Ornithorhynchus anatinus ENSOANG00000010554
30611 Otolemur garnettii ENSOGAG00000009418 132908 Pteropus vampyrus ENSPVAG00000005666
10116 Rattus norvegicus ENSRNOG00000026203 37347 Tupaia belangeri ENSTBEG00000008679
99883 Tetraodon nigroviridis ENSTNIG00000009029 9478 Tarsius syrichta ENSTSYG00000012543
8364 Xenopus tropicalis ENSXETG00000001272