Basic Information
Gene ID 8085 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name KMT2D; ALR, MLL2, MLL4
Full Name Histone-lysine N-methyltransferase 2D
Organism Homo sapiens [9606]

Cross Reference
UniProt O14686 UniGene Hs.731384
PDB 4ERQ OMIM 602113
KEGG hsa:8085 UCSC uc001rta.4

Protein Interactions
DIP DIP-37875N
IntAct O14686
MINT MINT-1192941
STRING 9606.ENSP00000301067

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000301067 Gene3D G3DSA:3.30.40.10 IPR013083 1376 1427 6.20e-08 Zinc finger, RING/FYVE/PHD-type
ENSP00000301067 Gene3D G3DSA:3.30.40.10 IPR013083 1428 1475 3.30e-14 Zinc finger, RING/FYVE/PHD-type
ENSP00000301067 Gene3D G3DSA:3.30.40.10 IPR013083 1505 1558 7.50e-08 Zinc finger, RING/FYVE/PHD-type
ENSP00000301067 Gene3D G3DSA:3.30.40.10 IPR013083 217 274 2.70e-08 Zinc finger, RING/FYVE/PHD-type
ENSP00000301067 Gene3D G3DSA:3.30.40.10 IPR013083 275 321 3.40e-13 Zinc finger, RING/FYVE/PHD-type
ENSP00000301067 Pfam PF00628 IPR019787 1379 1428 2.80e-07 Zinc finger, PHD-finger
ENSP00000301067 Pfam PF00628 IPR019787 1429 1476 3.20e-09 Zinc finger, PHD-finger
ENSP00000301067 Pfam PF00628 IPR019787 275 322 4.10e-09 Zinc finger, PHD-finger
ENSP00000301067 Pfam PF00856 IPR001214 5408 5513 3.20e-24 SET domain
ENSP00000301067 Pfam PF05964 IPR003888 5180 5232 1.10e-20 FY-rich, N-terminal
ENSP00000301067 Pfam PF05965 IPR003889 5237 5323 3.60e-25 FY-rich, C-terminal
ENSP00000301067 ProSiteProfiles PS50016 IPR019787 1377 1430 0.00e-00 Zinc finger, PHD-finger
ENSP00000301067 ProSiteProfiles PS50016 IPR019787 1427 1477 0.00e-00 Zinc finger, PHD-finger
ENSP00000301067 ProSiteProfiles PS50016 IPR019787 1504 1559 0.00e-00 Zinc finger, PHD-finger
ENSP00000301067 ProSiteProfiles PS50016 IPR019787 226 276 0.00e-00 Zinc finger, PHD-finger
ENSP00000301067 ProSiteProfiles PS50016 IPR019787 273 323 0.00e-00 Zinc finger, PHD-finger
ENSP00000301067 ProSiteProfiles PS50089 IPR001841 229 274 0.00e-00 Zinc finger, RING-type
ENSP00000301067 ProSiteProfiles PS50280 IPR001214 5397 5513 0.00e-00 SET domain
ENSP00000301067 ProSiteProfiles PS50868 IPR003616 5521 5537 0.00e-00 Post-SET domain
ENSP00000301067 ProSiteProfiles PS51542 IPR003888 5175 5235 0.00e-00 FY-rich, N-terminal
ENSP00000301067 ProSiteProfiles PS51543 IPR003889 5236 5321 0.00e-00 FY-rich, C-terminal
ENSP00000301067 SMART SM00184 IPR001841 1380 1427 5.60e-02 Zinc finger, RING-type
ENSP00000301067 SMART SM00184 IPR001841 1507 1556 4.10e-02 Zinc finger, RING-type
ENSP00000301067 SMART SM00184 IPR001841 172 217 2.20e-02 Zinc finger, RING-type
ENSP00000301067 SMART SM00184 IPR001841 229 273 2.00e-05 Zinc finger, RING-type
ENSP00000301067 SMART SM00184 IPR001841 276 320 1.00e-02 Zinc finger, RING-type
ENSP00000301067 SMART SM00184 IPR001841 5092 5136 1.90e-02 Zinc finger, RING-type
ENSP00000301067 SMART SM00249 IPR001965 1379 1428 3.50e-11 Zinc finger, PHD-type
ENSP00000301067 SMART SM00249 IPR001965 1429 1475 4.30e-15 Zinc finger, PHD-type
ENSP00000301067 SMART SM00249 IPR001965 1506 1557 5.60e-09 Zinc finger, PHD-type
ENSP00000301067 SMART SM00249 IPR001965 171 218 8.70e-08 Zinc finger, PHD-type
ENSP00000301067 SMART SM00249 IPR001965 228 274 9.90e-10 Zinc finger, PHD-type
ENSP00000301067 SMART SM00249 IPR001965 275 321 3.80e-14 Zinc finger, PHD-type
ENSP00000301067 SMART SM00249 IPR001965 5091 5137 1.90e-07 Zinc finger, PHD-type
ENSP00000301067 SMART SM00317 IPR001214 5397 5519 2.80e-38 SET domain
ENSP00000301067 SMART SM00398 IPR009071 2012 2080 9.90e-09 High mobility group box domain
ENSP00000301067 SMART SM00508 IPR003616 5521 5537 1.40e-07 Post-SET domain
ENSP00000301067 SMART SM00541 IPR003888 5191 5234 2.10e-23 FY-rich, N-terminal
ENSP00000301067 SMART SM00542 IPR003889 5240 5327 8.60e-46 FY-rich, C-terminal
ENSP00000301067 SUPERFAMILY SSF47095 IPR009071 2022 2072 0.00e-00 High mobility group box domain
ENSP00000301067 SUPERFAMILY SSF57903 IPR011011 1374 1428 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000301067 SUPERFAMILY SSF57903 IPR011011 1420 1480 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000301067 SUPERFAMILY SSF57903 IPR011011 1495 1564 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000301067 SUPERFAMILY SSF57903 IPR011011 215 274 0.00e-00 Zinc finger, FYVE/PHD-type
ENSP00000301067 SUPERFAMILY SSF57903 IPR011011 272 326 0.00e-00 Zinc finger, FYVE/PHD-type

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000301067 PF00628 2.7e-34 PHD PHD-finger
ENSP00000301067 PF05965 9.8e-26 FYRC F/Y rich C-terminus
ENSP00000301067 PF00856 3.2e-24 SET SET domain
ENSP00000301067 PF13771 8.8e-23 zf-HC5HC2H PHD-like zinc-binding domain
ENSP00000301067 PF05964 6e-21 FYRN F/Y-rich N-terminus
ENSP00000301067 PF13832 5.3e-11 zf-HC5HC2H_2 PHD-zinc-finger like domain
ENSP00000301067 PF00505 0.00038 HMG_box HMG (high mobility group) box

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000301067 GO:0051568 biological_process histone H3-K4 methylation
ENSP00000301067 GO:0005634 cellular_component nucleus
ENSP00000301067 GO:0035097 cellular_component histone methyltransferase complex
ENSP00000301067 GO:0008270 molecular_function zinc ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9597 Pan paniscus 100995808 39432 Saimiri boliviensis 101037539
9555 Papio anubis 101013975 9615 Canis familiaris 486558
9483 Callithrix jacchus ENSCJAG00000020845 10090 Mus musculus ENSMUSG00000048154
9986 Oryctolagus cuniculus ENSOCUG00000006202 30611 Otolemur garnettii ENSOGAG00000013443
9978 Ochotona princeps ENSOPRG00000015259 42254 Sorex araneus ENSSARG00000010487
9646 Ailuropoda melanoleuca ENSAMEG00000006918 9913 Bos taurus ENSBTAG00000014429
10141 Cavia porcellus ENSCPOG00000002973 10020 Dipodomys ordii ENSDORG00000006509
9365 Erinaceus europaeus ENSEEUG00000007930 9371 Echinops telfairi ENSETEG00000001399
9685 Felis catus ENSFCAG00000000093 9031 Gallus gallus ENSGALG00000025902
9595 Gorilla gorilla ENSGGOG00000007949 9785 Loxodonta africana ENSLAFG00000009989
30608 Microcebus murinus ENSMICG00000017547 59463 Myotis lucifugus ENSMLUG00000011179
9544 Macaca mulatta ENSMMUG00000015718 9669 Mustela putorius furo ENSMPUG00000014629
61853 Nomascus leucogenys ENSNLEG00000017849 9813 Procavia capensis ENSPCAG00000003597
9601 Pongo abelii ENSPPYG00000004478 9598 Pan troglodytes ENSPTRG00000004896
10116 Rattus norvegicus ENSRNOG00000015107 9823 Sus scrofa ENSSSCG00000000191
43179 Ictidomys tridecemlineatus ENSSTOG00000003904 37347 Tupaia belangeri ENSTBEG00000001207
9739 Tursiops truncatus ENSTTRG00000004737 8364 Xenopus tropicalis ENSXETG00000011176