Basic Information
Gene ID ENSSTOG00000006748
Gene Name ESR1
Full Name Estrogen receptor
Organism Ictidomys tridecemlineatus [43179]

Cross Reference
UniProt I3M8I7 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSSTOP00000006063 Gene3D G3DSA:1.10.565.10 IPR008946 237 267 2.20e-100 Nuclear hormone receptor, ligand-binding
ENSSTOP00000006063 Gene3D G3DSA:1.10.565.10 IPR008946 309 548 2.20e-100 Nuclear hormone receptor, ligand-binding
ENSSTOP00000006063 Gene3D G3DSA:3.30.50.10 IPR013088 183 236 9.60e-28 Zinc finger, NHR/GATA-type
ENSSTOP00000006063 Pfam PF00104 IPR000536 326 524 8.40e-29 Nuclear hormone receptor, ligand-binding, core
ENSSTOP00000006063 Pfam PF00105 IPR001628 182 250 2.20e-31 Zinc finger, nuclear hormone receptor-type
ENSSTOP00000006063 Pfam PF02159 IPR001292 42 179 1.00e-51 Oestrogen receptor
ENSSTOP00000006063 Pfam PF12743 IPR024736 552 594 4.60e-19 Oestrogen-type nuclear receptor final C-terminal domain
ENSSTOP00000006063 PIRSF PIRSF002527 IPR024178 42 590 2.50e-294 Oestrogen receptor/oestrogen-related receptor
ENSSTOP00000006063 PIRSF PIRSF500101 IPR001292 1 595 0.00e-00 Oestrogen receptor
ENSSTOP00000006063 PRINTS PR00047 IPR001628 183 199 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSSTOP00000006063 PRINTS PR00047 IPR001628 199 214 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSSTOP00000006063 PRINTS PR00047 IPR001628 232 240 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSSTOP00000006063 PRINTS PR00047 IPR001628 240 248 8.20e-17 Zinc finger, nuclear hormone receptor-type
ENSSTOP00000006063 PRINTS PR00398 IPR001723 244 254 1.70e-26 Steroid hormone receptor
ENSSTOP00000006063 PRINTS PR00398 IPR001723 347 368 1.70e-26 Steroid hormone receptor
ENSSTOP00000006063 PRINTS PR00398 IPR001723 368 384 1.70e-26 Steroid hormone receptor
ENSSTOP00000006063 PRINTS PR00398 IPR001723 436 451 1.70e-26 Steroid hormone receptor
ENSSTOP00000006063 PRINTS PR00398 IPR001723 506 523 1.70e-26 Steroid hormone receptor
ENSSTOP00000006063 PRINTS PR00543 IPR001292 113 129 3.90e-82 Oestrogen receptor
ENSSTOP00000006063 PRINTS PR00543 IPR001292 130 149 3.90e-82 Oestrogen receptor
ENSSTOP00000006063 PRINTS PR00543 IPR001292 151 170 3.90e-82 Oestrogen receptor
ENSSTOP00000006063 PRINTS PR00543 IPR001292 26 43 3.90e-82 Oestrogen receptor
ENSSTOP00000006063 PRINTS PR00543 IPR001292 45 62 3.90e-82 Oestrogen receptor
ENSSTOP00000006063 PRINTS PR00543 IPR001292 6 24 3.90e-82 Oestrogen receptor
ENSSTOP00000006063 PRINTS PR00543 IPR001292 69 84 3.90e-82 Oestrogen receptor
ENSSTOP00000006063 PRINTS PR00543 IPR001292 95 109 3.90e-82 Oestrogen receptor
ENSSTOP00000006063 ProSitePatterns PS00031 IPR001628 183 209 - Zinc finger, nuclear hormone receptor-type
ENSSTOP00000006063 ProSiteProfiles PS51030 IPR001628 180 255 0.00e-00 Zinc finger, nuclear hormone receptor-type
ENSSTOP00000006063 SMART SM00399 IPR001628 180 251 6.40e-40 Zinc finger, nuclear hormone receptor-type
ENSSTOP00000006063 SMART SM00430 IPR000536 346 518 3.10e-38 Nuclear hormone receptor, ligand-binding, core
ENSSTOP00000006063 SUPERFAMILY SSF48508 IPR008946 233 259 0.00e-00 Nuclear hormone receptor, ligand-binding
ENSSTOP00000006063 SUPERFAMILY SSF48508 IPR008946 300 547 0.00e-00 Nuclear hormone receptor, ligand-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSSTOP00000006063 PF02159 0 Oest_recep Oestrogen receptor
ENSSTOP00000006063 PF00105 1.4e-31 zf-C4 Zinc finger, C4 type (two domains)
ENSSTOP00000006063 PF00104 5.1e-29 Hormone_recep Ligand-binding domain of nuclear hormone receptor
ENSSTOP00000006063 PF12743 2.4e-19 ESR1_C Oestrogen-type nuclear receptor final C-terminal

Gene Ontology Annotation
Protein Entry Name Space Description
ENSSTOP00000006063 GO:0006351 biological_process transcription, DNA-templated
ENSSTOP00000006063 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSSTOP00000006063 GO:0007200 biological_process phospholipase C-activating G-protein coupled receptor signaling pathway
ENSSTOP00000006063 GO:0007204 biological_process positive regulation of cytosolic calcium ion concentration
ENSSTOP00000006063 GO:0010863 biological_process positive regulation of phospholipase C activity
ENSSTOP00000006063 GO:0030518 biological_process intracellular steroid hormone receptor signaling pathway
ENSSTOP00000006063 GO:0043124 biological_process negative regulation of I-kappaB kinase/NF-kappaB signaling
ENSSTOP00000006063 GO:0043433 biological_process negative regulation of sequence-specific DNA binding transcription factor activity
ENSSTOP00000006063 GO:0045429 biological_process positive regulation of nitric oxide biosynthetic process
ENSSTOP00000006063 GO:0051000 biological_process positive regulation of nitric-oxide synthase activity
ENSSTOP00000006063 GO:0051091 biological_process positive regulation of sequence-specific DNA binding transcription factor activity
ENSSTOP00000006063 GO:0071392 biological_process cellular response to estradiol stimulus
ENSSTOP00000006063 GO:0005634 cellular_component nucleus
ENSSTOP00000006063 GO:0005794 cellular_component Golgi apparatus
ENSSTOP00000006063 GO:0005886 cellular_component plasma membrane
ENSSTOP00000006063 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSSTOP00000006063 GO:0003707 molecular_function steroid hormone receptor activity
ENSSTOP00000006063 GO:0005496 molecular_function steroid binding
ENSSTOP00000006063 GO:0008270 molecular_function zinc ion binding
ENSSTOP00000006063 GO:0030284 molecular_function estrogen receptor activity
ENSSTOP00000006063 GO:0043565 molecular_function sequence-specific DNA binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9796 Equus caballus ENSECAG00000022441 8049 Gadus morhua ENSGMOG00000014898
9315 Macropus eugenii ENSMEUG00000003564 132908 Pteropus vampyrus ENSPVAG00000001923
13616 Monodelphis domestica 100027187 9555 Papio anubis 100303417
9986 Oryctolagus cuniculus 100351261 9483 Callithrix jacchus 100385918
9103 Meleagris gallopavo 100542782 61853 Nomascus leucogenys 100580202
10141 Cavia porcellus 100713276 10029 Cricetulus griseus 100768474
9597 Pan paniscus 100980011 39432 Saimiri boliviensis 101034130
9669 Mustela putorius furo 101690352 8083 Xiphophorus maculatus 102235986
13735 Pelodiscus sinensis 102456765 10090 Mus musculus 13982
9606 Homo sapiens 2099 9615 Canis familiaris 403640
28377 Anolis carolinensis ENSACAG00000006213 9646 Ailuropoda melanoleuca ENSAMEG00000011072
9913 Bos taurus ENSBTAG00000007159 7955 Danio rerio ENSDARG00000004111
10020 Dipodomys ordii ENSDORG00000010443 9365 Erinaceus europaeus ENSEEUG00000000828
9371 Echinops telfairi ENSETEG00000006131 9685 Felis catus ENSFCAG00000031492
69293 Gasterosteus aculeatus ENSGACG00000008711 9031 Gallus gallus ENSGALG00000012973
9595 Gorilla gorilla ENSGGOG00000009678 30608 Microcebus murinus ENSMICG00000007592
59463 Myotis lucifugus ENSMLUG00000014181 9258 Ornithorhynchus anatinus ENSOANG00000015561
30611 Otolemur garnettii ENSOGAG00000012580 8128 Oreochromis niloticus ENSONIG00000013354
9978 Ochotona princeps ENSOPRG00000012663 8090 Oryzias latipes ENSORLG00000014514
7757 Petromyzon marinus ENSPMAG00000008530 10116 Rattus norvegicus ENSRNOG00000019358
42254 Sorex araneus ENSSARG00000004419 99883 Tetraodon nigroviridis ENSTNIG00000012264
31033 Takifugu rubripes ENSTRUG00000018219 9478 Tarsius syrichta ENSTSYG00000006280
9739 Tursiops truncatus ENSTTRG00000002996 30538 Vicugna pacos ENSVPAG00000001185
8364 Xenopus tropicalis ENSXETG00000012364 37347 Tupaia belangeri ENSTBEG00000005946
59729 Taeniopygia guttata ENSTGUG00000011249