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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
Smad Brk bind1 Brk bound to a Dpp response element of the Ultrabithorax ( Ubx ) midgut enhancer at a sequence that overlaps a binding site for the Smad protein , Mothers Against Dpp ( Mad ) . 18 good bad
Smad BRCA2 associate2 Finally , analysis of a small cohort of hereditary breast cancers failed to reveal any association between BRCA1 or BRCA2 genotype and alterations in Smad signaling . 17 good bad
Smad neu associate1 Loss of Smad signaling was not associated with any particular histological subtype , histological or nuclear grade , estrogen- or progesterone receptor expression , or HER2 neu expression . 17 good bad
Smad Smad4 bind1 While there are two potential Smad binding elements ( SBE ' s ) in the TGFbeta ( 1 ) promoter , supershift assays suggest that at least one of these does not bind Smad4 , and the other is unable to bi 17 good bad
Smad tinman bind2 We show that the binding and synergistic activities of Smad and Tinman proteins are critical for mesodermal tinman induction , whereas repressor binding sites prevent induction in the dorsal ectoderm 17 good bad
Smad Brk complex1 In addition to the ligand-activated heteromeric receptor complex and the signal-transducing intracellular Smad proteins , Dpp signaling requires two nuclear proteins , Schnurri ( Shn ) and Brinker ( B 16 good bad
Smad tinman interact3 A similar regulatory interaction has been defined in Drosophila embryos where Dpp signaling mediated by the Smad homologues Mad and Medea directly regulates early cardiac expression of tinman . 15 good bad
Smad Smad4 complex3 Smad proteins activated by TGF-beta form complexes with Smad4 . 8 good bad
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Text2Knowledge ... Yong Huang 2002